Professor David Parkinson
Profiles

Professor David Parkinson

Professor of Neuroscience

Biomedical Research - Institute of Translational & Stratified Medicine (Faculty of Medicine and Dentistry)

Role

Professor of Neuroscience.

Research interests

My research interest in the control of myelination and repair in the peripheral nervous system (PNS). The  PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity. 

Key publications are highlighted

Journals
Articles
Dun X-P & Parkinson DB 2018 'Whole Mount Immunostaining on Mouse Sciatic Nerves to Visualize Events of Peripheral Nerve Regeneration' Methods Mol Biol 1739, 339-348 Author Site , DOI
Carr L, Parkinson DB & Dun X-P 2017 'Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system' PLoS One 12, (2) e0172736-e0172736 Author Site , DOI PEARL
Mindos T, Dun X-P, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL & Shivane A 2017 'Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity' The Journal of Cell Biology jcb.201606052-jcb.201606052 , DOI PEARL
Dun X-P & Parkinson D 2017 'Role of Netrin-1 Signaling in Nerve Regeneration' International Journal of Molecular Sciences 18, (3) 491-491 , DOI PEARL
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, D'Antonio M & Parkinson DB 2017 'Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve' Development Author Site , DOI PEARL
Roberts SL, Dun X-P, Dee G, Gray B, Mindos T & Parkinson DB 2017 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of Neurochemistry , DOI PEARL
Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB & Gehlhausen JR 2016 'The importance of nerve microenvironment for schwannoma development' Acta neuropathologica PEARL
Dun X-P & Parkinson DB 2015 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) Author Site , DOI PEARL
Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM & Giovannini M 2014 'Update from the 2013 International Neurofibromatosis Conference' AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164, (12) 2969-2978 Author Site , DOI
Shivane A, Parkinson DB, Ammoun S & Hanemann CO 2013 'Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas' HISTOPATHOLOGY 62, (4) 651-656 Author Site , DOI
Doddrell RDS, Dun X-P, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO & Parkinson DB 2013 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 Author Site , DOI PEARL
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C & Mautner V-F 2013 'Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy' Nature Neuroscience 16, (4) 426-433 , DOI
Kim HA, Mindos T & Parkinson DB 2013 'Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System' STEM CELLS TRANSLATIONAL MEDICINE 2, (8) 553-557 Author Site , DOI
Yang DP, Kim J, Syed N, Tung Y-J, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P & Parkinson DB 2012 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' J Neurosci 32, (21) 7158-7168 Author Site , DOI
Yang DP, Kim J, Syed N, Tung YJ, Bhaskaran A, Mindos TC, Mirsky R, Jessen KR, Maurel P & Parkinson DB 2012 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' The Journal of Neuroscience 32(21), 7158-7168
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB 2012 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' GLIA 60, (9) 1269-1278 Author Site , DOI
Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R & Jessen KR 2011 'Mouse schwann cells need both NRG1 and cyclic AMP to myelinate' Glia 59, (5) 720-733 Author Site , DOI
Mustafa M, Nabok A, Parkinson D, Tothill I, Salam F & Tsargorodskaya A 2010 'Detection of β-amyloid peptide (1–16) and amyloid precursor protein (APP770) using spectroscopic ellipsometry and QCM techniques: A step forward towards Alzheimers disease diagnostics' Biosensors and Bioelectronics 26, (4) 1332-1336 , DOI
Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH & Lloyd AC 2010 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 Author Site , DOI
Whiteman M, Li L, Rose P, Tan C-H, Parkinson DB & Moore PK 2010 'The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages' Antioxid Redox Signal 12, (10) 1147-1154 Author Site , DOI
Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P & Shen J 2009 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 Author Site , DOI
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A & Mirsky R 2008 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 Author Site , DOI PEARL
Flaiz C, Utermark T, Parkinson DB, Poetsch A & Hanemann CO 2008 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 Author Site , DOI
Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A & Jessen KR 2008 'Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation' J Peripher Nerv Syst 13, (2) 122-135 Author Site , DOI
Parkinson D, Bhaskaran A, rthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K 2007 'A central role for c-Jun in regulating the differentiation of Schwann cells' Neuron Glia Biology 2, S38-S38
Parkinson D, Bhaskaran A, Arthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K 2007 'A central role for c-Jun in regulating the differentiation of Schwann cells' NEURON GLIA BIOLOGY 2, S38-S38 Author Site
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR 2007 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' Journal of the Peripheral Nervous System 12, 2-2
Hossain S, Parkinson DB, Mushynski WE & Almazan G 2007 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' NEURON GLIA BIOLOGY 2, S138-S139 Author Site
Hossain S, Parkinson DB, Mushynski WE & Almazan G 2007 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' Neuron Glia Biology 2, S138-S139
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR 2007 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' NEURON GLIA BIOLOGY 2, S42-S42 Author Site
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR 2007 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' Neuron Glia Biology 2, S42-S42
Arthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K 2007 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' NEURON GLIA BIOLOGY 2, S133-S133 Author Site
rthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K 2007 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' Neuron Glia Biology 2, S133-S133
Parkinson D, Arthur-Farraj P, Jessen K & Mirsky R 2006 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24, (1) 159-169 , DOI
Parkinson 2006 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24 (1), 159-69 , DOI
Stephan C, Reidegeld KA, Hamacher M, van Hall A, Marcus K, Taylor C, Jones P, Müller M, Apweiler R & Martens L 2006 'Automated reprocessing pipeline for searching heterogeneous mass spectrometric data of the HUPO Brain Proteome Project pilot phase' PROTEOMICS 6, (18) 5015-5029 , DOI
Newton JRA, Parkinson D & Clench MR 2006 'Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms' Analytical and Bioanalytical Chemistry 385, (4) 692-699 , DOI
Reidegeld KA, Müller M, Stephan C, Blüggel M, Hamacher M, Martens L, Körting G, Chamrad DC, Parkinson D & Apweiler R 2006 'The power of cooperative investigation: Summary and comparison of the HUPO Brain Proteome Project pilot study results' PROTEOMICS 6, (18) 4997-5014 , DOI
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR 2005 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' Journal of Neurochemistry 94, 139-139
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'The function of Notch and stress kinase signals in early Schwann cell development' Journal of Neurochemistry 94, 2-2
Parkinson D, Bhaskaran A, Dickinson S & Droggiti A 2004 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' The Journal of Cell Biology 164, (3) 385-394 , DOI PEARL
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R & Jessen KR 2004 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC 2004 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' EMBO J 23, (15) 3061-3071 Author Site , DOI
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC 2004 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' Embo Journal 23, (15) 3061-3071
Parkinson D, Bhaskaran A, Dickinson S & Kinsella M 2003 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Mol Cell Neurosci 23, (1) 13-27 , DOI
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Alonso MBD, Mirsky R & Jessen KR 2003 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Molecular and Cellular Neuroscience 23, (1) 13-27
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N 2003 'Signals that regulate Schwann cell generation and myelination' Glia 7-7
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R 2002 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' GLIA S69-S69 Author Site
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R 2002 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' Glia S69-S69
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2002 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' GLIA S73-S73 Author Site
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2002 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' Glia S73-S73
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong Z, Meier C, Parmantier E & Lawson D 2002 'Schwann cells as regulators of nerve development' J Physiol Paris 96, (1-2) 17-24 Author Site
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong ZP, Meier C, Parmantier E & Lawson D 2002 'Schwann cells as regulators of nerve development' Journal of Physiology-Paris 96, (1-2) 17-24
Parkinson DB, Langner K, Namini SS, Jessen KR & Mirsky R 2002 'β-Neuregulin and Autocrine Mediated Survival of Schwann Cells Requires Activity of Ets Family Transcription Factors' Molecular and Cellular Neuroscience 20, (1) 154-167 , DOI
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2001 'Krox-20 protects Schwann cells from TGF beta mediated cell death' Molecular Biology of the Cell 12, 28A-28A
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2001 'Krox-20 protects Schwann cells from TGF beta mediated cell death' MOLECULAR BIOLOGY OF THE CELL 12, 28A-28A Author Site
Mirsky R, Parkinson DB, Dong Z, Meier C, Calle E, Brennan A, Topilko P, Harris BS, Stewart HJ & Jessen KR 2001 'Regulation of genes involved in Schwann cell development and differentiation' Prog Brain Res 132, 3-11 Author Site , DOI
Parkinson DB, Dong ZP, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R & Jeesen KR 2001 'Transforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation' Journal of Neuroscience 21, (21) 8572-8585
Parkinson D, Bunting H, Dong Z & Whitfield J 2001 'Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation' J Neuroscience 21, (21) 8572-8585
Shepherd C, Bowes S, Parkinson D, Cambray-Deakin M & Pearson R 2000 'Expression of amyloid precursor protein in human astrocytes in vitro: isoform-specific increases following heat shock' Neuroscience 99, (2) 317-325 , DOI
Campbell E, Pearson R & Parkinson D 1999 'Methods to uncover an antibody epitope in the KPI domain of Alzheimer’s amyloid precursor protein for immunohistochemistry in human brain' Journal of Neuroscience Methods 93, (2) 133-138 , DOI
Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R & Jessen KR 1999 'Schwann cell development in embryonic mouse nerves' J Neurosci Res 56, (4) 334-348 Author Site , DOI
Perlmutter JS, Tempel LW, Black KJ, Parkinson D & Todd RD 1997 'MPTP induces dystonia and parkinsonism: Clues to the pathophysiology of dystonia' Neurology 49, (5) 1432-1438 , DOI
Barnett PV, Pullen L, Staple RF, Lee LJ, Butcher R, Parkinson D & Doel TR 1996 'A protective anti-peptide antibody against the immunodominant site of the A24 Cruzeiro strain of foot-and-mouth disease virus and its reactivity with other subtype viruses containing the same minimum binding sequence' Journal of General Virology 77, (5) 1011-1018 , DOI
Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santiago JV & McDaniel ML 1994 'Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface' Diabetes 43, (3) 418-425 Author Site
Parkinson D 1992 'Carboxypeptidase H in bovine pituitary gland: Soluble forms are not processed at the C-terminus' Molecular and Cellular Endocrinology 86, (3) 221-233 , DOI
Fiedorek FT & Parkinson D 1992 'Carboxypeptidase H processing and secretion in rat clonal beta-cell lines' Endocrinology 131, (3) 1054-1062 Author Site , DOI
Baumrind NL, Parkinson D, Wayne DB, Heuser JE & Pearlman AL 1992 'EMA: A developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones' Developmental Dynamics 194, (4) 311-325 , DOI
Moerlein SM, Banks WR & Parkinson D 1992 'Production of fluorine-18 labeled (3-N-methyl)benperidol for PET investigation of cerebral dopaminergic receptor binding' International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 43, (7) 913-917 , DOI
McCullough K, Pullen L & Parkinson D 1992 'The immune response against foot-and-mouth disease virus: influence of the T lymphocyte growth factors IL-1 and IL-2 on the murine humoral response in vivo' Immunology Letters 31, (1) 41-46 , DOI
Spira AW & Parkinson D 1991 'Effects of dark-rearing on the retinal dopaminergic system in the neonatal and postnatal guinea pig' Developmental Brain Research 62, (1) 142-145 , DOI
Gordon B, Daw N & Parkinson D 1991 'The effect of age on binding of MK-801 in the cat visual cortex' Developmental Brain Research 62, (1) 61-67 , DOI
McIntosh H & Parkinson D 1990 'GAP-43 in adult visual cortex' Brain Research 518, (1-2) 324-328 , DOI
McIntosh H, Daw N & Parkinson D 1990 'GAP-43 in the cat visual cortex during postnatal development' Visual Neuroscience 4, (06) 585-593 , DOI
Lannoye GS, Moerlein SM, Parkinson D & Welch MJ 1990 'N-Fluoroalkylated and N-alkylated analogs of the dopaminergic D-2 receptor antagonist raclopride' Journal of Medicinal Chemistry 33, (9) 2430-2437 , DOI
Moerlein SM, Parkinson D & Welch MJ 1990 'Radiosynthesis of high effective specific-activity [123I]SCH 23982 for dopamine D-1 receptor-based SPECT imaging' International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 41, (4) 381-385 , DOI
Parkinson D 1990 'Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences' J Biol Chem 265, (28) 17101-17105 Author Site
McIntosh H, Parkinson D, Meiri K, Daw N & Willard M 1989 'A GAP-43-like protein in cat visual cortex' Visual Neuroscience 2, (06) 583-591 , DOI
Craig J, Parkinson D, Goatley L & Knowles N 1989 'Assay sensitivity and differentiation of monoclonal antibody specificity in ELISA with different coating buffers' Journal of Biological Standardization 17, (3) 281-289 , DOI
Parkinson D 1989 'Evidence for a dopaminergic innervation of cat primary visual cortex' Neuroscience 30, (1) 171-179 , DOI
Parkinson D, Coscia EC & Daw NW 1989 'Identification and localization of 5-hydroxytryptamine receptor sites in macaque visual cortex' Visual Neuroscience 2, (05) 515-525 , DOI
Sorenson EM, Parkinson D, Dahl JL & Chiappinelli VA 1989 'Immunohistochemical localization of choline acetyltransferase in the chicken mesencephalon' The Journal of Comparative Neurology 281, (4) 641-657 , DOI
Daw NW, Brunken WJ & Parkinson D 1989 'The Function of Synaptic Transmitters in the Retina' Annual Review of Neuroscience 12, (1) 205-225 , DOI
Craig J, Parkinson D & Knowles N 1989 'The suitability of different microtitre plates for detection of antibody to virus antigens by indirect ELISA' Journal of Biological Standardization 17, (2) 125-135 , DOI
Parkinson D, Kratz KE & Daw NW 1988 'Evidence for a nicotinic component to the actions of acetylcholine in cat visual cortex' Experimental Brain Research 73, (3) 553-568 , DOI
Parkinson D, Coscia E & Daw NW 1988 'Identification and localization of adrenergic receptors in cat visual cortex' Brain Research 457, (1) 70-78 , DOI
McCullough KC, Parkinson D & Crowther JR 1988 'Opsonization-enhanced phagocytosis of foot-and-mouth disease virus' Immunology 65, (2) 187-191 Author Site
Gredal O, Parkinson D & Nielsen M 1987 'Binding of [3H]SCH 23390 to dopamine D-1 receptors in rat retina in vitro' European Journal of Pharmacology 137, (2-3) 241-245 , DOI
Daw NW, Baysinger KJ & Parkinson D 1987 'Increased levels of testosterone have little effect on visual cortex plasticity in the kitten' Journal of Neurobiology 18, (2) 141-154 , DOI
Hannah R, Parkinson D, Spira A & Roth S 1987 'The effect of chlorpromazine on monoamine levels in the rat cerebellum and hippocampus: a developmental study' Neuroscience Letters 79, (1-2) 133-137 , DOI
Loewy A, Marson L, Parkinson D, Perry M & Sawyer W 1986 'Descending noradrenergic pathways involved in the A5 depressor response' Brain Research 386, (1-2) 313-324 , DOI
Daw NW, Videen TO, Parkinson D & Rader RK 1985 'DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) depletes noradrenaline in kitten visual cortex without altering the effects of monocular deprivation' J Neurosci 5, (7) 1925-1933 Author Site
Parkinson D 1985 'Sensitive analysis of butyrophenone neuroleptics by high-performance liquid chromatography with ultraviolet detection at 254 nm' Journal of Chromatography B: Biomedical Sciences and Applications 341, 465-472 , DOI
Parkinson D, Spira A, Wyse J & Patten M 1985 'The ontogenesis of the dopaminergic cell in the pre- and postnatal guinea pig retina' International Journal of Developmental Neuroscience 3, (2) 157-167 , DOI
Parkinson D & Rando RR 1984 'Ontogenesis of dopaminergic neurons in the post-natal rabbit retina: pre- and post-synaptic elements' Brain Res 315, (2) 207-217 Author Site
Parkinson D & Rando RR 1984 'Ontogenesis of dopaminergic neurons in the post-natal rabbit retina: Pre- and post-synaptic elements' Developmental Brain Research 13, (2) 207-217 , DOI
McCullough K & Parkinson D 1984 'The standardization of a ‘spot-test’ ELISA for the rapid screening of sera and hybridoma cell products I. The determination of the optimum buffering system' Journal of Biological Standardization 12, (1) 67-74 , DOI
McCullough K & Parkinson D 1984 'The standardization of a ‘spot-test’ ELISA for the rapid screening of sera and hybridoma cell products II. The determination of binding capacity, binding ratio and coefficient of variation of different ELISA plates in sandwich and indirect ELISA' Journal of Biological Standardization 12, (1) 75-86 , DOI
Parkinson D & Redshaw JD 1984 'Visible labeling of proteins for polyacrylamide gel electrophoresis with dabsyl chloride' Analytical Biochemistry 141, (1) 121-126 , DOI
Parkinson D & Rando RR 1983 'Effect of light on dopamine turnover and metabolism in rabbit retina' Invest Ophthalmol Vis Sci 24, (3) 384-388 Author Site
Parkinson D & Rando RR 1983 'Effects of Light on Dopamine Metabolism in the Chick Retina' Journal of Neurochemistry 40, (1) 39-46 , DOI
McCullough K, Butcher R & Parkinson D 1983 'Hybridoma cell lines secreting monoclonal antibodies against foot-and-mouth disease virus (FMDV). II. Cloning conditions' Journal of Biological Standardization 11, (3) 183-194 , DOI
McCullough K, Butcher R & Parkinson D 1983 'Hybridoma cell lines secreting monoclonal antibodies against foot-and-mouth disease virus. 1. Cell culturing requirements' Journal of Biological Standardization 11, (3) 171-181 , DOI
Watling KJ, Parkinson D & Dowling JE 1982 'Effects of intraocular injections of 6-hydroxydopamine on dopamine-dependent cyclic AMP accumulation in intact pieces of carp retina' Brain Research 253, (1-2) 334-336 , DOI
Parkinson D & Callingham BA 1982 'Irradiation Inactivation Analysis of Acetylcholinesterase and the Effect of Buffer Salts' Radiation Research 90, (2) 252-252 , DOI
Rando RR, Coburn J & Parkinson D 1982 'The Differential Effects of GABA-Transaminase Inactivation in the Chick Retina and Brain' Journal of Neurochemistry 39, (4) 1147-1151 , DOI
Parkinson D, Baughman R, Masland RH & Rando RR 1981 'Dopamine metabolism following irreversible inactivation of aromatic amino acid decarboxylase in retina' J Neurosci 1, (11) 1205-1210 Author Site
Parkinson D & Rando RR 1981 'Evidence for a neurotransmitter role for 5-hydroxytryptamine in chick retina' J Neurosci 1, (11) 1211-1217 Author Site
PARKINSON D, LYLES GA, BROWNE BJ & CALLINGHAM BA 1980 'Some factors influencing the metabolism of benzylamine by type A and B monoamine oxidase in rat heart and liver' Journal of Pharmacy and Pharmacology 32, (1) 844-850 , DOI
PARKINSON D & CALLINGHAM BA 1980 'The binding of [3H] pargyline to rat liver mitochondrial monoamine oxidase' Journal of Pharmacy and Pharmacology 32, (1) 49-54 , DOI
Parkinson D & Callingham BA 1979 'Substrate and inhibitor selectivity of human heart monoamine oxidase' Biochemical Pharmacology 28, (10) 1639-1643 , DOI
Parkinson D & Callingham BA 1978 'Post-mortem stability of monoamine oxidase in rat tissues' Journal of Pharmacy and Pharmacology 30, (1) 648-651 , DOI
Callingham BA & Parkinson D 1977 'The inhibition of human heart monoamine oxidase [proceedings]' Br J Pharmacol 61, (3) 470P-471P Author Site
Reviews
Kim HA, Mindos TC & Parkinson DB 2014 'Plastic fantastic: Schwann cells and repair of the peripheral nervous system' Stem Cells Translational Medicine 2 (8), 553-557
Conference Papers
Mindos T, Dun X-P, North K, Schulz A, Gray B, Pan D, Edwards P, Shivane A, Morrison H & Parkinson D 2017 'The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling' E40-E41
Mindos T, Edwards P, Shivane AG & Parkinson DB 2017 'The role of macrophages in human schwannomas' 18-18
Roberts S, Dunn XP, Doddrell R & Parkinson D 2015 'Analysing the role of Sox2 in regulating Schwann cell myelination during development and after injury' E274-E275
Mindos T, Roberts S, Dun X-P, Edwards P, Doddrell R, Shivane A & Parkinson D 2015 'The Merlin tumour suppressor is critical for peripheral nerve regeneration and repair' E423-E424
North K, Mindos T, Dun X-P & Parkinson D 2015 'The role of Hippo/YAP signalling in Schwann cell development and peripheral nerve repair' E437-E437
Mindos T, Roberts S, Doddrell R, Mortimer G, Dun XP, Edwards P, Shivane A & Parkinson D 2015 'The role of the Merlin tumour suppressor in the developing and injured adult peripheral nerve' 54-54
Mortimer G, Dun X, Doddrell RDS, Wrabetz L, Feltri ML & Parkinson DB 2013 'EXAMINING THE ROLE OF THE MERLIN TUMOUR SUPPRESSOR IN PERIPHERAL NERVE DEVELOPMENT AND REPAIR' 75-75
Schulz A, Baader S, Niwa-Kawakita M, Bauer R, Jung J, Zoch A, Schacke S, Hagel C, Mautner V & Hanemann O 2013 'THE ROLE OF MERLIN ISOFORM 2 IN NEUROFIBROMATOSIS TYPE 2-ASSOCIATED POLYNEUROPATHY' S104-S104
Shivane A, Ammoun S, Parkinson DB & Hanemann CO 2012 'EXPRESSION OF C-JUN & SOX-2 IN HUMAN SCHWANNOMAS AND TRAUMATIC NEUROMAS' 9-10
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB 2012 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' United States 1269-1278 , DOI
Doddrell RDS, Goodchild E & Parkinson DB 2010 'Role of the transcription factor Sox-2 in the control of peripheral nerve development and repair' S20-S20 , DOI
Doddrell R, Hanemann CO & Parkinson DB 2009 'REGULATION OF CELL DIFFERENTIATION IN MERLIN NULL TUMOURS' S170-S170
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR 2007 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' 2-2
Woodhoo A, Duran Alonso M, Parkinson DB, Mirsky R, Jessen KR & MEDIMOND 2005 'Factors affecting the early life of a Schwann cell' 139-143
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR 2005 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' 139-139
Parkinson DB, Bhaskaran A, Mirsky R, Jessen KR & MEDIMOND 2005 'Regulation of the myelinating phenotype of Schwann cells by Krox-20' 37-42
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'Signals that control glial cell specification in the PNS' 148-148
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'The function of Notch and stress kinase signals in early Schwann cell development' 2-2 , DOI
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N 2003 'Signals that regulate Schwann cell generation and myelination' 7-7
Moerlein SM, Perlmutter JS, Bockhorst JL, Parkinson D & Welch MJ 1994 'N-alkylated analogues of [F-18]benperidol as dopaminergic D-2 receptor ligands' 462-463