Dr Edwin Lasonder
Profiles

Dr Edwin Lasonder

Associate Professor in Proteomics

School of Biomedical Sciences (Faculty of Medicine and Dentistry)

Role

Associate Professor in Proteomics

Admissions Tutor MSc Biomedical Sciences

Qualifications

PhD Medical Sciences, University of Goningen, The Netherlands (1995)

Drs Organic Chemistry, University of Groningen, The Netherlands (1990)

Professional membership

- European Virtual Institute of Malaria Research

   http://www.evimalar.org/

- Malsig 

   http://www.malsig.lille.inserm.fr/

Teaching interests

Proteomics Seminars  (undergraduate and postgraduate students) and Proteomics Workshops (postgraduate students)


Research interests

 My general research interest is the application of massspectrometry–based proteomics in biomedical research with a particular interestfor the human diseases malaria and cancer.

 The most severe form of malaria is caused by the infection of the parasite Plasmodium falciparum when an infected Anopheles mosquito takes a blood meal. Currently, about half of the 5500 P.falciparum genes are not functionally annotated due to poor homology with other species.  We apply proteome mining and proteome expression profiling for creating a proteomic catalogue of proteins expressed in all of the life cycle stages.  So far,we have characterised about 2600 P.fal proteins across seven developmental life cycle stages in human and mosquito hosts. The most recent work is focussed on establishing the parasite phosphoproteome in infected red blood cells(schizonts, merozoites) to decipher parasite-specific signalling pathways that allow development of new anti-malarial drugs.


Current projects

  1. The identification of the P.falciparum signalling pathways and mechanisms of red blood cell invasion and motility by a comparative phosphoproteome analysis of merozoites schizonts. Collaborators: dr A. Holder (MRC, London), dr G.Langsley (Institut Cochin, Paris, France), dr P.Alano (ISS, Rome, Italy)
  2. The P. falciparum proteome of male and female gametocytes. Collaborators: Dr. B. van Schaijk, prof dr R. Sauerwein (Radboud University Medical Centre, Nijmegen, The Netherlands)
  3. The identification of the signalling pathways that cause accelerated aging of red blood cells through infection of P. falciparum. Collaborators:dr G.Langsley (Institut Cochin, Paris, France)
  4. Dendriomics of Human DCs Cells Subsets; an integrated analysis of the transcriptome and proteome of human dendritic cells in vivo. Collaborators:K. Worah, dr S. Buschow and prof.dr. C.G. Figdor (Radboud University Medical Centre, Nijmegen, The Netherlands)
  5. Identifying common therapeutic targets in schwannomas and meningiomas brain tumours. Collaborators: K. Bassiri and prof dr. O.Hanemann  (Peninsula Medical School, Plymouth University)

Grants & contracts

- European Virtual Institute of Malaria Research

- MALSIG