- 122, DRF, Drake Circus, Plymouth, PL4 8AA
- +44 1752 584455
- gyorgy.fejer@plymouth.ac.uk
Profiles
Dr Gyorgy Fejer
Associate Professor of Infection and Immunity
School of Biomedical Sciences (Faculty of Health)
Biography
Biography
Lecturer in environmental pathogens
Qualifications
PhD in medicine, Semmelweis Medical School, 1998
Residency in Microbiology, 1995
PGCAP in Teaching and Learning in Higher Education, Plymouth University, 2013
Professional membership
British Society for Immunology (BSI)
Key publications
(2011) 'Human Toll-like receptor 4: A crucial receptor for the development of contact eczema to metal haptens' S94-S94
(2013) 'Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions' Proc Natl Acad Sci U S A 110, (24) E2191-E2198 , DOI
(2010) 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 , DOI
(2008) 'Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo' PLoS Pathog 4, (11) , DOI Open access
(2008) 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 , DOI
(2005) 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 , DOI
Research
Research
Research interests
Molecular mechanisms of lung macrophage functions in health and disease
Macrophages are crucially involved in various diseases such as Infectious and environmental pathogen induced conditions, cancer and metabolic disorders and also in normal tissue homeostasis. These cells exhibit, depending on their anatomical location, distinct biological properties. Studies exploring macrophages are of high scientific and clinical interest, but are hampered by the limited life-span and restricted numbers of primary tissue macrophages that can be obtained for such experiments. We established a novel, continuously growing, non-transformed model of lung alveolar macrophages (AMs), cells that play key roles in important diseases such as lung infection, asthma and chronic obstructive pulmonary disease (COPD). This model can replace and reduce in vivo studies involving macrophages and can contribute to the saving of lives of a very high number of experimental animals. Importantly, using our new system the detailed molecular analysis of scarcely available alveolar macrophages is possible. This made possible the identification of several, previously unknown innate immune phenomena in AMs (Fejer et al; PNAS 2013). Our laboratory now analyses the underlying molecular details using methods of molecular immunology, cell biology and proteomics. These studies help to understand relevant mechanisms of AM biology and lung diseases and can contribute to the development of drugs that influence AM activity in various pathology states.
Research groups
Publications
Publications
Key publications
(2011) 'Human Toll-like receptor 4: A crucial receptor for the development of contact eczema to metal haptens' S94-S94
(2013) 'Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions' Proc Natl Acad Sci U S A 110, (24) E2191-E2198 , DOI
(2010) 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 , DOI
(2008) 'Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo' PLoS Pathog 4, (11) , DOI Open access
(2008) 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 , DOI
(2005) 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 , DOI
Key publications are highlighted
Journals
Articles
(2024) 'Type I interferon, induced by adenovirus or adenoviral vector infection, regulates the cytokine response to LPS in a macrophage type-specific manner' J Innate Immun , DOI
(2024) 'Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages' European Journal of Immunology Publisher Site , DOI
(2024) 'Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome' Cell Reports 43, (3) 113935-113935 Publisher Site , DOI
(2023) 'Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen' Nature Communications 14, (1) , DOI Open access
(2022) 'Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells' Bioscience Reports , DOI Open access
(2022) 'Micro and nano-plastics, a threat to human health?' EMERGING TOPICS IN LIFE SCIENCES 6, (4) 411-422 , DOI
(2020) 'Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing' PLOS Neglected Tropical Diseases 14, (1) e0007897-e0007897 , DOI Open access
(2019) 'Time-resolved characterization of the mechanisms of toxicity induced by silica and amino-modified polystyrene on alveolar-like macrophages' Archives of Toxicology 94, (1) 173-186 , DOI Open access
(2019) 'Evaluation of the proinflammatory effects of contaminated bathing water' Journal of Toxicology and Environmental Health, Part A 82, (20) 1076-1087 , DOI
(2018) 'Isolation of Oropouche Virus from Febrile Patient, Ecuador' Emerging Infectious Diseases 24, (5) 935-937 , DOI Open access
(2018) 'Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages' Frontiers in Immunology 9, , DOI Open access
(2018) 'Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor' PLOS Pathogens 14, (3) 0-0 , DOI Open access
(2017) 'A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages' Scientific Reports 7, (1) , DOI Open access
(2017) 'Erratum for Maler et al., “Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages”' mBio 8, (5) , DOI Open access
(2017) 'Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages' mBio 8, (4) 0-0 , DOI Open access
(2015) 'Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor' ACS Applied Materials & Interfaces 7, (42) 23527-23537 , DOI Open access
(2015) 'Self-renewing macrophages--a new line of enquiries in mononuclear phagocytes' Immunobiology 220, (2) 169-174 , DOI
(2013) 'Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions' Proc Natl Acad Sci U S A 110, (24) E2191-E2198 , DOI
(2011) 'Adenovirus-triggered innate signalling pathways' Eur J Microbiol Immunol (Bp) 1, (4) 279-288 , DOI
(2011) 'Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells' J Immunol 186, (9) 5478-5488 , DOI
(2010) 'Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC' J Exp Med 207, (12) 2703-2717 , DOI Open access
(2010) 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 , DOI
(2009) 'Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis' J Virol 83, (18) 9411-9422 , DOI
(2008) 'Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo' PLoS Pathog 4, (11) , DOI Open access
(2008) 'Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity' J Exp Med 205, (9) 2151-2162 , DOI Open access
(2008) 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 , DOI
(2008) 'Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity' Immunobiology 213, (3-4) 193-203 , DOI
(2007) 'Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells' J Virol 81, (23) 13242-13247 , DOI
(2005) 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 , DOI
(2005) 'Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes' J Immunol 174, (7) 4295-4300 , DOI
(2004) 'Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter' J Biol Chem 279, (28) 28911-28919 , DOI
(2004) 'PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing' Nat Immunol 5, (3) 299-308 , DOI
(2003) 'Phosphorus-based SAHA analogues as histone deacetylase inhibitors' Org Lett 5, (17) 3053-3056 , DOI
(2003) 'The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication' J Gen Virol 84, (Pt 6) 1451-1462 , DOI
(2003) 'Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1' Genes Dev 17, (8) 1019-1029 , DOI
(2003) 'Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines' J Immunol 170, (6) 3125-3133 , DOI
(2002) 'Mechanisms of histone deacetylases' FASEB JOURNAL 16, (4) A3-A3
(1998) 'Soluble interleukin 6 (IL-6) receptor influences the expression of the protooncogene junB and the production of fibrinogen in the HepG2 human hepatoma cell line and primary rat hepatocytes' Cytokine 10, (8) 620-626 , DOI
(1998) 'Development of competitive mRNA PCR for the quantification of interleukin-6-responsive junB oncogene expression' Biotechniques 24, (5) 854-860 , DOI
(1998) 'Interleukin-6 activates the adenovirus early region 3 promoter' EUROPEAN CYTOKINE NETWORK 9, (3) 303-303
(1995) 'Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice' J Virol 69, (12) 7674-7681 , DOI
(1995) 'Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes' Proc Natl Acad Sci U S A 92, (15) 6947-6951 , DOI
(1995) 'MULTIPLE FUNCTIONS OF ADENOVIRUS E3 IMMUNOREGULATORY GENES - EFFECTS ON ACUTE VIRAL PATHOGENESIS AND PROLONGATION OF SURVIVAL OF PANCREATIC-ISLET ALLOGRAFTS' JOURNAL OF CELLULAR BIOCHEMISTRY 279-279
(1995) 'Model systems for studying the effects of adenovirus E3 genes on virulence in vivo' Curr Top Microbiol Immunol 199 ( Pt 3), 195-211 , DOI
(1994) 'Characterization of transgenic mice containing adenovirus early region 3 genomic DNA' J Virol 68, (9) 5871-5881 , DOI
(1992) 'Multiple enlargements in the right inverted terminal repeat of the DNA of canine adenovirus type 2' Acta Microbiol Hung 39, (2) 159-168
(1990) 'Characterization of an intermediate adenovirus strain' Acta Microbiol Hung 37, (3) 315-318
(1989) 'RELATIONSHIP OF E1 AND E3 REGIONS OF HUMAN ADENOVIRUS-35 TO THOSE OF HUMAN ADENOVIRUS SUBGROUP-A, SUBGROUP-C AND SUBGROUP-D' ACTA MICROBIOLOGICA HUNGARICA 36, (4) 445-457
(1989) 'Molecular cloning and physical mapping of the DNA of human adenovirus type 35' Acta Microbiol Hung 36, (1) 67-75
(1989) 'Relationship of E1 and E3 regions of human adenovirus 35 to those of human adenovirus subgroups A, C and D' Acta Microbiol Hung 36, (4) 445-457
(1988) 'RABBIT-CELL CLONES TRANSFORMED BY THE ONCOGENE OF SIMIAN ADENOVIRUS 16' ACTA MICROBIOLOGICA HUNGARICA 35, (2) 211-211
Conference Papers
(2016) 'A novel alveolar-like macrophage to study influenza A infection <i>in vitro</i>' 438-438
(2016) 'Development and characterization of a novel cell-based biosensor for screening of inflammatory agents in bioaerosols' 1176-1176
(2015) 'Adenovirus binding to the scavenger receptor SR-A6 (MARCO) triggers the production of inflammatory cytokines in alveolar macrophages' A13-A13
(2014) 'MPI-2 cells, a new model for tissue type macrophages' E24-E24
(2013) 'Establishment of self-renewing, non-transformed, GM-CSF dependent macrophages, a new model to study lung alveolar macrophage functions' 33-33
(2011) 'Murine CD8α+ DCs and human BDCA3+ DCs produce large amounts of IFN-λ in response to poly IC and DNA viruses (154.6)' The American Association of Immunologists 154.6-154.6 , DOI
(2011) 'Murine CD8α+ DCs and human CD141+DCs produce large amounts of IFN-λ in response to dsRNA or DNA viruses' 65-65 , DOI
(2011) 'Human Toll-like receptor 4: A crucial receptor for the development of contact eczema to metal haptens' S94-S94
(2003) 'The transcription factor PRDI-BF1 establishes an inactive chromatin state by recruitment of histone methyltransferases' C100-C101
Presentations and posters
'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel'
'POTENTIAL FOR REGULATION OF TOLL LIKE RECEPTOR 4 ACTIVITY BY LYSINE ACETYLATION'
'Upregulated innate immune responses in a hepatitis C virus exposed uninfected cohort' , DOI