Professor Ji-Liang Li
Profiles

Professor Ji-Liang Li

Professor/Chair in Cancer Immunology

Biomedical Research - Institute of Translational & Stratified Medicine (Faculty of Medicine and Dentistry)

Role

Professor & Chair of Cancer Immunology
Plymouth University Faculty of Medicine and Dentistry

Qualifications

  • PhD, Molecular Medicine, London School of Tropical Medicine & Hygiene, University of London, UK
  • MMed, Medicine, Sun Yat-Sen University College of Medicine, Guangzhou, China
  • MD, Medicine, Suzhou Medical College, Suzhou, China
Previous positions
  • 2007–2015:   Deputy Lab Head/Tenured Senior Scientist, Weatherall Institute of Molecular Medicine, University of Oxford, UK;
  • 2002–2007:   Tenured Staff Scientist/Deputy Lab Head, Cancer Research UK (CRUK), UK;
  • 1999–2002:   Research Fellow, Imperial Cancer Research Fund (ICRF), UK;
  • 1996–1999:   Postdoc Research Associate, Department of Biochemistry, University of Oxford, UK.

Professional membership

  • American Association for Cancer Research

Roles on external bodies

Invited Peer Review for Research Grants/Fellowships
  • MRC
  • BBSRC
  • NWO (Netherlands Organisation for Scientific Research)
  • HRC (Health Research Council of New Zealand)
  • NMRC (Singapore National Medical Research Council)
  • Newton Foundation Prize
  • Breast Cancer Now
  • British Heart Foundation
  • Daphne Jackson Trust
Invited Peer Review for >40 Professional Journals    
  • Gut
  • Blood
  • Cancer Research
  • Clinical Cancer Research                      
  • Oncogene
  • Journal of Pathology 
Editorial/Scientific Board Members    

Teaching interests

Cancer Biology and Cancer Immunology

Research interests

My research interest focuses on tumour microenvironment and translational cancer medicine. By employing a variety of approaches including molecular biology, cell biology, immunology, proteomics, next-generation sequencing, bioinformatics, animal models, human tumour samples and relevant clinical data, my research is dedicated to delineate mechanisms on how key molecules (such as microRNAs, lncRNAs, and RN181 E3 ligase), signalling pathways (such as Notch signalling), tumour cells, and tumour stromal cells (such as endothelial cells, infiltrating lymphocytes, tumour-associated macrophages, and tumour-associated fibroblasts) in tumour microenvironment regulate tumour growth and metastasis and tumour response to therapeutic interventions (in particular, cross-interactions among radiotherapy, chemotherapy, targeted therapy and immunotherapy). My aims are (1) to dissect mechanisms of tumour migration, invasion and metastasis, (2) to develop novel therapeutic targets or biomarkers, and (3) to improve therapeutic efficacy by optimal combinations of radiotherapy, chemotherapy, targeted therapy, or immunotherapy. Primary cancer types I am currently working on include, but not limit to, brain tumour (eg, gliomas), breast cancer, gastrointestinal tumour (eg, gastric, colorectal and liver cancer), and head & neck cancer (eg, nasopharyngeal carcinoma). 

Tumour Microenvironment and Translational Cancer Medicine 

  • Cancer Immunology
  • Tumour associated macrophage
  • Tumour invasion and metastasis
  • Hypoxia and angiogenesis pathways 
  • Notch signalling in cancer biology 
  • Cancer-associated lncRNAs and MicroRNAs
  • Tumour resistance to therapeutic treatments
  • Optimal combination therapy 
  • Preclinical mouse tumour models

Representative Publications

  1. Cai L, Ye Y, Jiang Q, Chen Y, Lyu X, et al. (2015): Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma. Nature Commun. Jul 2; 6:7353. doi:10.1038/ncomms8353.
  2. Masiero M, Simões FC, Han HD, Snell C, Peterkin T, et al. (2013): A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell. Aug 12; 24(2):229-41. 
  3. Li JL, Sainson RC, Oon CE, Turley H, Leek R, et al. (2012): DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Res. Sep 15; 71(18):6073-83. 
  4. Wang S, Huang X, Li Y, Lao H, Zhang Y, et al. (2011): RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. Hepatology. Jun; 53(6):1932-42.
Graduate Student, Clinical Fellow, Visiting Fellow and Postdoctoral Positions: Enquiries with CV welcome at any time.

Currently, both Senior Research Fellow in Cancer Biology (A5980) and Research Assistant in Cancer Biology (A5965) are available immediately.

Several self-funded PhD studentships and visiting fellows will be expected in 2019/2020.

In addition, we welcome talented and enthusiastic people to join us. We will be more than happy to sponsor researcher with a strong track record and passion on cancer translational research who would rather apply for his/her own fellowship/scholarship such as Newton International Fellowships (open Jan-Mar); Marie Curie Individual Fellowships (open Apr-Sep); EMBO Fellowships; Commonwealth Rutherford Fellowships (http://bit.ly/cscuk-rutherford); China Scholarship Council etc.


Selected Publications (10 key publications are highlighted by linking to the journal website)

  1. Dong N, Shi X, Wang S, Gao Y, Kuang Z, Xie Q, Li Y, Deng H, Wu Y, Li M, *Li JL. (2019): M2 macrophages mediate sorafenib resistance by secreting HGF in a feed-forward manner in hepatocellular carcinoma. British Journal of Cancer, https://doi.org/10.1038/s41416-019-0482-x. (*corresponding author).
  2. Li Y, Wang H, Li X, Li H, Zhang Q, Zhou H, He Y, Li P, Fu C, Zhang X, Qiu Y, *Li JL. (2019): Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus. Clinical Science, Apr 2; 133(7): 821-838. DOI: 10.1042/CS20180841. (*corresponding author).
  3. Chen Y, Huang L,  Wang S, Li JL, Li M, Wu Y, Liu T. (2019): WFDC2 contributes to epithelial-mesenchymal transition (EMT) by activating AKT signaling pathway and regulating MMP-2 expression. Cancer Management and Research, Mar 27; 11:2415-2424. DOI: https://doi.org/10.2147/CMAR.S192950.
  4. Wang S, Wang X, Gao Y, Peng Y, Dong N, Xie Q, Zhang X, Wu Y, Li M, *Li JL. (2018): RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway. The Journal of Pathology, Feb 3; 248(2):204-216. DOI: 10.1002/path.5246. (*corresponding author).
  5. Chen Y, Huang L, Wang S, Liu T, Wu Y, *Li JL, Li M. (2017): WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associate genes. J Ovarian Res. Jul 5; (10(1):40. DOI: 10.1186/s13048-017-0329-0. (*corresponding author).
  6. Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A,Turley H, Leek R, Buffa F, Harris AL, *Li, J.L. (2017): Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth. Oncotarget, Jun 20; 8(25):40115-40131. DOI: 10.18632/oncotarget.16969. (*corresponding author).
  7. da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S, Bridges E, Li JL, Knapp S, Ebner D, Klamt F, Harris AL, McIntyre A. (2017): The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer. Oncogene, Jan 5; 36(1):122-132. DOI: 10.1038/onc.2016.184.
  8. McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL. (2016): Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth. Cancer Research, Jul 1; 76(13):3744-3755. DOI: 10.1158/0008-5472.CAN-15-1862.
  9. Fan SJ, Snell C, Turley H, Li JL, McCormick R, Perera SM, Heublein S, Kazi S, Azad A, Wilson C, Harris AL, Goberdhan DC. (2016): PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer. Oncogene, Jun 9; 35(23):3004-3015. DOI: 10.1038/onc.2015.363.
  10. He P, Wang S, Zhang X, Gao Y, Niu W, Dong N, Shi X, Geng Y, Ma Q, Li M, Jiang B, *Li JL. (2016): Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer. Oncotarget, May 20; 7(26): 40160-40173. DOI: 10.18632/oncotarget.9514. (*corresponding author)
  11. Chen Y, Wang S, Liu T, Wu Y, *Li JL, Li M. (2016): WAP four-disulfide core domain protein 2 gene (WFDC2) is a target of estrogen in ovarian cancer cells. J Ovarian Res., Feb 29; 9:10. DOI: 10.1186/s13048-015-0210-y. (*corresponding author)
  12. He B, Xiao YF, Tang B, Wu YY, Hu CJ, Xie R, Yang X, Yu ST, Dong H, Zhao XY, *Li JL, Yang SM. (2016): hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a. Scientific Reports, Feb 23; 6:21955. DOI: 1038/srep21955. (*corresponding author).
  13. Yang, J., Tahan, A.A., Jones, D.T., Buffa, F.M., Bridges, E., Interiano, R.B., Qu, C., Vogt, N., Li, J.L. et al. (2015): Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer. Proc Natl Acad Sci USA., Dec 8; 112(49): 15172-15177. doi: 10.1073/pnas.1422015112. 
  14. Ramcharan, R., Aleksic, T., Gao, S., Kamdoum, W.P., Tanner, J., Bridges, E., Asher, R., Watson, A.J., Margison, G.P., Woodcock, M., Repapi, E., Li, J.L., Middleton, M.R. and Macaulay, V.M. (2015): IGF-1R inhibition induces schedule-dependent sensitization of melanoma to temozolomide. Oncotarget, Nov 24; 6(37): 39877-39890. doi: 10.18632/oncotarget.5631.
  15. Ledaki, I., McIntyre, A., Wigfield, S., Buffa, F., McGowan, S., Baban, D., Li, J.L. and Harris, A.L. (2015): Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Oncotarget, Aug 14; 6(23):19413-19427. DOI: 10.18632/oncotarget.4989
  16. Cai, L., Ye, Y., Jiang, Q., Lyu, X., Chen,Y., Li, J., Wang, S., Liu, T., Yao, K., *Li, J.L. and Li, X. (2015): Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma. Nature Commun., July 2; 6:7353. doi:10.1038/ncomms8353. (*corresponding and co-senior author).  
  17. Leung, W.Y., Roxanis, J., Sheldon, H., Buffa, F.M., Li, J.L., Harris, A.L. and Kong, A. (2015): Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signaling in HER2 amplified breast cancer. Oncotarget, Mar 20; 6(8): 5678-5694. DOI: 10.18632/oncotarget.3296
  18. Zhao W., Yin, J., Yang, Z., Xie, J., Zhang, Y., Xu, W. and *Li, J.L. (2015): Meta-analysis of androgen insensitivity in preoperative hormone therapy in hypospadias. Urology, May; 85(5): 1166-1172. doi: 10.1016/j.urology.2015.01.035. (*corresponding author)
  19. Singleton, D., Rouhi, P., Haider, S., Zois, C.E., Li, J.L., Kessler, B.M., Cao, Y. and Harris, A.L. (2015): Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene, Sep 3; 34(36): 4713-4722. doi: 10.1038/onc.2014.396. 
  20. Bensaad, K., Favaro, E., Lewis, C.A., Lord, S., Collins, J.M., Pinnick, K., Buffa, F., Li, J.L. et al. (2014): Fatty acid uptake and lipid storage induced by HIF-1a contribute to cell survival in hypoxia-reoxygenation. Cell Report, Oct 9; 9(1): 349-365. doi: 10.1016/j.celrep.2014.08.056.
  21. Feldinger, K., Generali, D., Kramer-Marek, G., Gijsen, M., Ng, T.B., Wong, J.H., Strina, C., Cappelletti, M., Andreis, D., Li, J.L. et al. (2014): ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. Oncotarget, Aug 30; 5(16):6633-6646. DOI: 10.18632/oncotarget.1955.
  22. Lyu, X., Fang, W., Zheng, H., Cai, L., Ye, Y., Zhang, L., Li, J., Peng, H., Cho, W.C, Wang, E., Marincola, F.M., Yao, K., Cai, H., *Li, J.L. and Li, X. (2014): TGFβR2 is a major target of microRNA-93 in nasopharyngeal carcinoma aggressiveness. Molecular Cancer, Mar 8; 13(1): 51. doi: 10.1186/1476-4598-13-51.  (*corresponding author).
  23. Mohd Nafi, S.N., Generali, D., Kramer-Marek, G., Gijsen, M., Cappelletti, M., Andreis, D., Haider, S., Li, J.L. et al. (2014): Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer. Oncotarget, Aug 15; 5(15): 5934-5949. DOI: 10.18632/oncotarget.1904.
  24. Canonici, A.,Gijsen, M., Mullooly, M., Bennett, R., Bouguern, N., Pedersen, K., O’Brien, N.A., Roxanis, I., Li, J.L. et al. (2013): Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer. Oncotarget, Oct; 4(10):1592-605. DOI: 10.18632/oncotarget.1148.
  25. Masiero, M., Simões, F.C., Han, H.D., Snell, C., Peterkin, T., Bridges, E., Mangala, L.S., Wu, S.Y., Pradeep, S., Li, D., Han, C., Dalton, H., Lopez-Berestein, G., Tuynman, J.B., Mortensen, N., Li, J.L. et al. (2013): A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell, Aug 12; 24(2): 229-241. doi: 10.1016/j.ccr.2013.06.004.
  26. Kumar,K., Wigfield, S., Gee, H.E., Devlin, C.M., Singleton, D., Li, J.L., Buffa, F., Huffman, M., Sinn, A.L., Silver, J., Turley, H., Leek, R., Harris, A.L. and Ivan, M. (2013): Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhance its antitumor effects in mouse xenografts. Journal of Molecular Medicine, Jun; 91(6):749-758. doi: 10.1007/s00109-013-0996-2. 
  27. Whiteman, P., Hernandez de Madrid, B., Taylor, P., Li, D., Heslop, R., Vichitcheep, N., Tan, J.Z., Shimizu, H., Callaghan, J., Masiero, M., Li, J.L. et al. (2013): Molecular basis for Jagged-1/Serrate recognition by Notch. The Journal of Biological Chemistry, Mar 8; 288(10):7305-7312. doi: 10.1074/jbc.M112.428854.
  28. Pike, L.R., Singleton, D.S., Buffa, F., Abramczyk, O., Phadwal, K., Li, J.L., Simon, A.K., Murray, J.T. and Harris, A.L. (2013): Transcriptional upregulation of ULK1 by ATF4 contributes to cancer cell survival. Biochemical Journal, Jan 15; 449(2): 389-400. doi: 10.1042/BJ20120972.
  29. Chen,Y., Mu, X., Wang, S., Zhao, L., Wu Y., *Li, J.L. and Li, M. (2013): WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncology Reports, Jan; 29(1): 288-296. doi: 10.3892/or.2012.2114. (*corresponding author).
  30. Favaro, E., Bensaad, K., Chong, M.G., Tennant, D.A., Ferguson, D.J., Snell, C., Steers, G., Turley, H., Li, J.L. et al. (2012): Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence incancer cells. Cell Metabolism, Dec 5; 16(6): 751-764. doi: 10.1016/j.cmet.2012.10.017.
  31. Jones, D.T., Lechertier, T., Mitter, R., Herbert, J.M., Bicknell, R., Jones, J.L., Li,J.L., Buffa, F., Harris, A.L. and Hodivala-Dilke, K. (2012): Gene expression analysis in human breast cancer associated blood vessels. PLoS ONE, 7(10): e44294. doi: 10.1371/journal.pone.0044294.
  32. McIntyre, A., Patiar, S., Wigfield, S., Li, J.L., Ledaki, I., Turley,H., Leek, R., Snell, C., Gatter, K.C., Sly, W.S., Vaughan-Jones, R.D., Swietach, P. and Harris, A.L. (2012): Carbonic anhydrase IX promotes tumour growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. Clinical Cancer Research, Jun 1; 18(11):3100-3111. doi: 10.1158/1078-0432.CCR-11-1877.
  33. *Li, J.L., Sanson, R.C., Oon, C.E., Turley, H., Leek, R., Sheldon, H., Bridges, E., Shi, W., Snell, C., Bowden, E.T., Wu, H., Chowdhury, P.S., Russell, A.J., Montgomery, C.P., Poulsom, R. and Harris, A.L. (2011): DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo. Cancer Research, Sep 15; 71(18): 6073-6083. doi: 10.1158/0008-5472.CAN-11-1704. (*corresponding author).
  34. Wang, S., Huang, X., Li, Y., Lao, H., Zhang, Y., Dong, H., Xu, W., *Li, J.L. and Li, M. (2011): RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. Hepatology, Jun; 53(6): 1932-1942. doi: 10.1002/hep.24291. (*corresponding author).
  35. Coutts, A.S., Pires, I.M., Weston, L., Buffa, F.M., Milani, M., Li, J.L., Harris, A.L., Hammond, E.M. and La Thangue, N.B. (2011): Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. Oncogene, Dec 1; 30(48): 4835-4842. doi: 10.1038/onc.2011.
  36. Sheldon, H., Heikamp, E., Turley, T., Dragovic, R., Thomas, P., Oon, C.E., Leek. R., Edelmann, M., Kessler, B., Sainson, R.C., Sargent, I., Li, J.L. and Harris, A.L. (2010): New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood, Sep 30; 116(13): 2385-2394. doi: 10.1182/blood-2009-08-239228.
  37. Chen, L., Zeng,X., Wang, J., Briggs, S.S., O’Neill, E., Li, J.L. et al. (2010): Roles of tetrahydrobiopterin in promoting tumor angiogenesis. The American Journal of Pathology, Nov; 177(5):2671-2680. 
  38. *Li, J.L., Jubb, A.M. and Harris, A.L. (2010): Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity. Future Oncology, Jul; 6(7): 1099-1103. (*corresponding author).
  39. Favaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.L., Vojnovic, B., deNeves, R.P., Glazer, P., Iborra, F., Ivan, M., Ragoussis, J. and Harris, A.L. (2010): MicroRNA-210 regulates mitochondrial free radical response to hypoxia and Krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS ONE, Apr 26; 5(4): e10345.
  40. Biswas, S., Troy, H., Leek, R., Chung, Y.L., Li, J.L., Raval, R., Turley, H., Gatter, K., Pezzella, F., Griffiths, J.R., Stubbs, M. and Harris, A.L. (2010): Effects of HIF-1a and HIF-2a on growth and metabolism of clear-cell renal cell carcinoma 786-0 xenografts. Journal of Oncology, 2010; 2010: 757908.
  41. Jubb, A.M., Soilleux, E.J., Turley, H., Steers, G., Parker, A., Low, I., Li, J.L., Leek, R., Noguera-Troise, I., Pezzella, F., Gatter, K.C., Thurston, G. and Harris, A.L. (2010): Prognostic impact of Delta-like ligand 4 (Dll4) and inflammatory markers in breast cancer. The American Journal of Pathology, Apr; 176(4): 2019-2028.
  42. Pires, I.M., Bencokova, Z., Milani, M., Folkes, L.K., Li, J.L., Stratford, M.R., Harris, A.L. and Hammond, E.M. (2010): Chronic hypoxia leads to replisome disassembly and an inhibition of the DNA damage response. Cancer Research, Feb 1; 70(3): 925-935.
  43. Hao, J.M., Chen, J.Z., Sui, H.M., Si-Ma, H.Q., Li, G.Q., Liu, C., Li,J.L., Ding, Y.Q. and Li, J.M. (2010): A five-gene signature as a predictor of metastasis and survival in colorectal cancer. The Journal of Pathology, Mar; 220(4): 475-489.
  44. Jubb, A.M., Turley, H., Moeller, H.C., Steers, G., Han, C., Li, J.L., Leek, R., Singh, B., Mortensen, N.J., Noguera-Troise, I., Pezzella, F., Gatter, K.C., Fox, S.B., Thurston, G. and Harris, A.L. (2009): Expression of delta-like ligand4 (Dll4) and markers of hypoxia in colon cancer. British Journal of Cancer, 101(10): 1749-1757.
  45. Yang, J., Ledaki, I., Turley, H., Gatter, K.C., Montero, J-C., Li, J.L., and Harris, A.L. (2009): Role of hypoxic inducible factors in epigenetic regulation via histone demethylases. Annals of the New York Academy of Sciences, Oct; 1177:185-197.
  46. Martinez, J.C., Müller, M.M., Turley, H., Steers, G., Choteau, L., Li, J.L., Sainson, R., Harris, A.L., Pezzella, F. and Gatter, K.C. (2009): Nuclear and membrane expression of the angiogenesis regulator Delta-like ligand 4 (DLL4) in normal and malignant human tissues. Histopathology, Apr; 54(5):598-606.
  47. *Li, J.L. (2009): DNA replication in the human malaria parasite and potential for novel drug development. In “Molecular Themes in DNA Replication” Edited by Lynne S Cox, published by the Royal Society of Chemistry, ISBN: 978-0-85404-164-0,Chapter 13, 363-392. (*corresponding author).
  48. *Li, J.L. and Harris, A.L. (2009): Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Frontiers in Bioscience, Jan 1; 14: 3094-3110. (*corresponding author).
  49. Harrington, L.S., Sainson, R.C., Williams, C.K., Taylor, J.M., Shi, W., Li, J.L. and Harris, AL. (2008): Regulation of multiple angiogenic pathways by DLL4 andNotch in human umbilical vein endothelial cells. Microvascular Research, Mar; 75(2): 144-154.
  50. *Li, J.L., Sainson, R.C., Shi, W., Leek, R., Harrington, L.S., Preusser, M., Biswas, S., Turley, H., Heikamp, E., Hainfellner, J.A. and Harris, A.L. (2007): Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Research, Dec 1; 67(23): 11244-11253. (*corresponding author).
  51. *Li, J.L. and Harris, A.L. (2007): The potential of new tumor endothelium-specific markers for the development of anti-vascular therapy. Cancer Cell, Jun; 11(6):478-482. (*corresponding author).
  52. Patel, N.S., Dobbie, M. S., Rochester, M., Steers, G., Poulsom, R., Cranston, D.W., Li, J.L. and Harris, A.L. (2006):Up-regulation of endothelial Delta-like 4 expression correlates with vessel maturation in bladder cancer.  Clinical Cancer Research, Aug 15; 12(16): 4836-4844.
  53. Williams, C.K., Li, J.L., Murga, M., Harris, A.L. and Tosato,G. (2006): Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood, Feb 1; 107(3): 931-939.
  54. *Li, J.L. and Harris, A.L. (2006): Notch signalingfrom tumor cells: a new mechanism of angiogenesis. Cancer Cell, Jul; 8(1): 1-4. (*corresponding author).
  55. Patel, N.S., *Li, J.L., Generali, D., Poulsom, R., Cranston, D.W. and Harris, A.L. (2005): Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Research, Oct 1; 65(19): 8690-8697. (*corresponding author).
  56. Raval, R.R., Lau, K.W., Tran, M.G., Sowter, H.M., Mandriota, S.J., Li, J.L., Pugh, C.W., Maxwell, P.H., Harris, A.L. and Ratcliffe, P.J. (2005): Contrasting properties of hypoxia-inducible factor HIF-1 and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology, Jul; 25(13): 5675-5686.
  57. Jiao, R., Bachrati, C.Z., Pedrazzi, G., Kuster, P., Petkovic, M., Li, J.L., Egli, D., Hickson, I.D. and Stagljar, I. (2004): Physical and functional interaction between the Bloom’s syndrome gene product and the largest subunit of chromatin assembly factor 1. Molecular and Cellular Biology, Jun; 24(11): 4710-4719.
  58. Braybrooke, J.P.,  *Li, J.L., Wu, L., Caple, F., Benson, F.E. and Hickson, I.D. (2003): Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D). The Journal of Biological Chemistry, Nov 28; 278(48): 48357-48366. (*co-first author).
  59. *Li, J.L. and Cox, L.S. (2003): Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum. Parasitology International, Mar; 52(1): 41-52. (*corresponding author).
  60. *Li, J.L., Warren, A.V. and Cox, L.S. (2002): Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum. International Journal for Parasitology, Dec 19; 32(14): 1683-1692. (*corresponding author).
  61. Yang, Q., Zhang, R., Wang, X., Spillare, E.A., Linke, S.P., Subramanian, D., Griffith, J.D., Li, J.L., Hickson, I.D., Shen, J.C., Loeb, L.A., Mazur, S.J., Appella, E., Brosh, R.M. Jr, Karmakar, P., Bohr, V.A. and Harris,C.C. (2002): The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. The Journal of Biological Chemistry, Aug 30; 277(35): 31980-31987.
  62. Li, J.L., Brosh, R.M., Bohr, V.A., Neidle, S. and Hickson, I.D. (2001): Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands. Biochemistry, Dec 18; 40(50): 15194-15202.
  63. *Li, J.L. and Cox, L.S. (2001): Identification of an MCM4 homologue expressed specifically in the sexual stage of Plasmodium falciparum. International Journal for Parasitology, Sep; 31(11): 1246-1252. (*corresponding author).
  64. *Li, J.L., Targett, G.A.T. and Baker, D.A. (2001): Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum. International Journal for Parasitology, Apr; 31(4): 387-392. (*corresponding author).
  65. Hickson, I.D., Davies, S.L., Li, J.L., Levitt N.C., Mohaghegh, P., North, P.S. and Wu, L. (2001): Role of the Bloom's syndrome helicase in maintenance of genome stability. Biochemical Society Transactions, May; 29(2):201-204.
  66. Karow, J.K., Constantinou, S., Li, J.L., West, S.C. and Hickson, I.D. (2000): The Bloom’s syndrome gene product promotes branch migration of Holliday junctions. Proc Natl Acad Sci U S A., Jun 6; 97(12):6504-6508.
  67. Brosh, R.M., Li, J.L., Kenny, M.K., Karow, J.K., Cooper, M.P., Kureekattil, R.P., Hickson, I.D. and Bohr, V.A. (2000): Replication protein A physically interacts with the Bloom syndrome protein and stimulates its helicase activity. The Journal of Biological Chemistry, Aug 4; 275(31): 23500-23508.
  68. Li, G.D., Li, J.L., Mugthin, M. and Ward, S.A. (2000): Molecular cloning of a gene encoding a 20S proteasome b-subunit from Plasmodium falciparumInternational Journal for Parasitology, May; 30(6): 729-733.
  69. *Li, J.L. and Cox, L.S. (2000)Isolation and characterisation of a cAMP-dependent protein kinase catalytic subunit from Plasmodium falciparum. Molecular and Biochemical Parasitology, Jul; 109(2): 157-163. (*corresponding author).
  70. *Li, J.L., Baker,D.A. and Cox, L.S. (2000): Sexual stage-specific expression of a third calcium-dependent protein kinase of Plasmodium falciparum. Biochimica et Biophysica Acta, Apr 25; 1491(1-3): 341-349. (*corresponding author).          
  71. Carucci, D.J., Witney, A.A., Muhia, D.K., Warhurst, D.C., Schaap, P., Meima, M., Li, J.L., Taylor, M.C., Kelly, J.M. and Baker, D.A. (2000): Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. The Journal of Biological Chemistry, Jul 21; 275(29): 22147-22156.
  72. Baker, D.A. and *Li, J.L. (1999): A family of PP2 phosphatases in Plasmodium falciparum and parasitic protozoa. Parasitology Today, Mar; 15(3): 124-. (*corresponding author).
  73. *Li, J.L. and Baker, D.A. (1998): A putative protein serine/threonine phosphatase from Plasmodium falciparum contains a large N-terminal extension and five unique inserts in the catalytic domain. Molecular and Biochemical Parasitology, Sep15; 95(2): 287-295. (*corresponding author).
  74. *Li, J.L. and Baker,D.A. (1997): Protein phosphatase b, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparumEuropean Journal of Biochemistry, Oct 1; 249(1): 98-106. (*corresponding author).
  75. *Li, J.L., Robson, K.J.H., Chen, J.L., Targett, G.A.T. and Baker, D.A. (1996): Pfmrk, a MO15-related kinase from Plasmodium falciparum: cloning, sequence, stage-specific expression and chromosome localization. European Journal of Biochemistry, Nov 1; 242(2): 805-813. (*corresponding author).
  76. *Li, J.L., Li, Y.J., Chao, S., Ouyang, M.H. and Peng, Y.B. (1993): Serum-free medium for long-term growth, freezing, cloning and fusion of myelomas and hybridomas. In Vitro Cellular and Developmental Biology, Feb; 29A(2): 87-88. (*corresponding author).
  77. *Li, J.L., Chen, J.L., Ouyang, M.H., Chao, S., Peng, Y.B., Lin, L.X.M., Chang, W.S. and Li, Y.J. (1991): Immunization strategies for the production of rat monoclonal anti-idiotype antibodies. Journal of Immunological Methods, Aug 28; 142(1): 15-20. (*corresponding author).
  78. *Li, J.L., Li, Y.J.,Chao,S., Lin, L.X.M., Ouyang, M.H., Peng, Y.B. and Chang, W.S. (1991): Cholesterol requirement for growth of IR983F and P3X63-Ag8-U1 myeloma cells in serum-free medium. Cytobios, 68(272): 15-22. (*corresponding author).

GenBank Submission (accession number)

Li JL et al.:  U73195; U88869; U89025; AF056205; AF056206; AF065397; AF069296; AF071408; AF071409; AF083323; AF093702; AF095948; AF104915; AF106064; AF126257; AF126719; AF139108; AF139827; AF170073;  AF251283;  AF251284;  AF284763;  AF356553; AF373219.

Key publications are highlighted

Journals
Articles
Li Y, Wang H, Li X, Li H, Zhang Q, Zhou H, He Y, Li P, Fu C 2019 'Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus' Clinical Science CS20180841-CS20180841 , DOI PEARL
Chen Y, Huang L, Wang S, Li J-L, Li M, Wu Y & Liu T 2019 '<p><em>WFDC2</em> contributes to epithelial&ndash;mesenchymal transition (EMT) by activating AKT signaling pathway and regulating MMP-2 expression</p>' Cancer Management and Research Volume 11, 2415-2424 , DOI
Wang S, Wang X, Gao Y, Peng Y, Dong N, Xie Q, Zhang X, Wu Y, Li M 2019 'RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway' The Journal of Pathology , DOI PEARL
Chen Y, Huang L, Wang S, Liu T, Wu Y, Li J-L & Li M 2017 'WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes' Journal of Ovarian Research 10, (1) , DOI PEARL
Oon CE, Bridges E, Sheldon H, Sainson RCA, Jubb A, Turley H, Leek R, Buffa F, Harris AL 2017 'Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth' Oncotarget 8, (25) , DOI PEARL
da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S 2016 'The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer' Oncogene , DOI PEARL
He P, Wang S, Zhang X, Gao Y, Niu W, Dong N, Shi X, Geng Y, Ma Q 2016 'Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer' Oncotarget , DOI PEARL
McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E 2016 'Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth' Cancer Research 76, (13) 3744-3755 , DOI PEARL
Chen Y, Wang S, Liu T, Wu Y, Li J-L & Li M 2016 'WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cells' Journal of Ovarian Research 9, (1) , DOI PEARL
Yang J, AlTahan A, Jones DT, Buffa FM, Bridges E, Interiano RB, Qu C, Vogt N, Li J-L 2015 'Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer' Proceedings of the National Academy of Sciences 112, (49) 15172-15177 , DOI PEARL
Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ 2015 'IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide' Oncotarget 6, (37) , DOI PEARL
Ramcharan R, Aleksic T, Kamdoum WP, Gao S & Pfister SX 2015 'IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide' Oncotarget 6, (37) 39879-39890 , DOI
Ramcharan R, Aleksic T, Gao S, Kamdoum WP, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, Woodcock 2015 'IGF-1R inhibition induces schedule-dependent sensitization of melanoma to temozolomide' Oncotarget , DOI PEARL
Fan S-J, Snell C, Turley H, Li J-L, McCormick R, Perera SMW, Heublein S, Kazi S, Azad A 2015 'PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer' Oncogene 35, (23) 3004-3015 , DOI PEARL
Ledaki I, McIntyre A, Wigfield S, Buffa F, McGowan S, Baban D, Li J-L & Harris AL 2015 'Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition' Oncotarget 6, (23) , DOI PEARL
Cai L, Ye Y, Jiang Q, Chen Y, Lyu X, Li J, Wang S, Liu T, Cai H 2015 'Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma' Nature Communications 6, (1) , DOI PEARL
Zhao W, Yin J, Yang Z, Xie J, Zhang Y, Xu W & Li J-L 2015 'Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias' Urology 85, (5) 1166-1172 , DOI PEARL
Leung W-Y, Roxanis I, Sheldon H, Buffa FM, Li J-L, Harris AL & Kong A 2015 'Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer' Oncotarget 6, (8) , DOI PEARL
Singleton DC, Rouhi P, Zois CE, Haider S, Li J-L, Kessler BM, Cao Y & Harris AL 2014 'Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis' Oncogene 34, (36) 4713-4722 , DOI PEARL
Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM 2014 'Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation' Cell Reports 9, (1) 349-365 , DOI PEARL
Nafi SNM, Generali D, Kramer-Marek G, Gijsen M, Strina C, Cappelletti M, Andreis D, Haider S, Li J-L 2014 'Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer' ONCOTARGET 5, (15) 5934-5949 Author Site PEARL
Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C, Cappelletti M, Andreis D 2014 'ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer' Oncotarget 5, (16) , DOI PEARL
Nafi SNM, Generali D, Kramer-Marek G, Gijsen M, Strina C, Cappelletti M, Andreis D, Haider S, Li J-L 2014 'Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer' Oncotarget 5, (15) , DOI PEARL
Lyu X, Fang W, Cai L, Zheng H, Ye Y, Zhang L, li J, Peng H, Cho WCS 2014 'TGFβR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness' Molecular Cancer 13, (1) 51-51 , DOI PEARL
Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY-Y, Pradeep S 2013 'A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis' Cancer Cell 24, (2) 229-241 , DOI PEARL
Canonici A, Gijsen M, Mullooly M, Bennett R, Bouguern N, Pedersen K, O’Brien NA, Roxanis I, Li J-L 2013 'Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer' Oncotarget 4, (10) , DOI PEARL
Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li J-L, Buffa F, Huffman M, Sinn AL 2013 'Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts' Journal of Molecular Medicine 91, (6) 749-758 , DOI PEARL
Whiteman P, de Madrid BH, Taylor P, Li D, Heslop R, Viticheep N, Tan JZ, Shimizu H, Callaghan J 2013 'Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor' Journal of Biological Chemistry 288, (10) 7305-7312 , DOI PEARL
Pike LRG, Singleton DC, Buffa F, Abramczyk O, Phadwal K, Li J-L, Simon AK, Murray JT & Harris AL 2013 'Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival' Biochemical Journal 449, (2) 389-400 , DOI PEARL
Favaro E, Bensaad K, Chong MG, Tennant DA, Ferguson DJP, Snell C, Steers G, Turley H, Li J-L 2012 'Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells' Cell Metabolism 16, (6) 751-764 , DOI PEARL
CHEN YAO, MU XIA, WANG SUIHAI, ZHAO LIANG, WU YINGSONG, LI JILIANG & LI MING 2012 'WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes' Oncology Reports 29, (1) 288-296 , DOI PEARL
Jones DT, Lechertier T, Mitter R, Herbert JMJ, Bicknell R, Jones JL, Li J-L, Buffa F, Harris AL 2012 'Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels' PLoS ONE 7, (10) e44294-e44294 , DOI PEARL
McIntyre A, Patiar S, Wigfield S, Li J-L, Ledaki I, Turley H, Leek R, Snell C, Gatter K 2012 'Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy' Clinical Cancer Research 18, (11) 3100-3111 , DOI PEARL
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P 2012 'Guidelines for the use and interpretation of assays for monitoring autophagy' Autophagy 8, (4) 445-544 , DOI
Li J-L, Sainson RCA, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C 2011 'DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo' Cancer Research 71, (18) 6073-6083 , DOI PEARL
Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li J-L, Harris AL, Hammond EM & La Thangue NB 2011 'Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α' Oncogene 30, (48) 4835-4842 , DOI PEARL
Wang S, Huang X, Li Y, Lao H, Zhang Y, Dong H, Xu W, Li J-L & Li M 2011 'RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway' Hepatology 53, (6) 1932-1942 , DOI PEARL
Chen L, Zeng X, Wang J, Briggs SS, O'Neill E, Li J, Leek R, Kerr DJ, Harris AL 2010 'Roles of Tetrahydrobiopterin in Promoting Tumor Angiogenesis' The American Journal of Pathology 177, (5) 2671-2680 , DOI PEARL
Li J-L, Jubb AM & Harris AL 2010 'Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity' Future Oncology 6, (7) 1099-1103 , DOI PEARL
Sheldon H, Heikamp E, Turley H, Dragovic R, Thomas P, Oon CE, Leek R, Edelmann M, Kessler B 2010 'New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes' Blood 116, (13) 2385-2394 , DOI PEARL
Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F 2010 'MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU' PLoS ONE 5, (4) e10345-e10345 , DOI PEARL
Jubb AM, Soilleux EJ, Turley H, Steers G, Parker A, Low I, Blades J, Li J-L, Allen P 2010 'Expression of Vascular Notch Ligand Delta-Like 4 and Inflammatory Markers in Breast Cancer' The American Journal of Pathology 176, (4) 2019-2028 , DOI PEARL
Pires IM, Bencokova Z, Milani M, Folkes LK, Li J-L, Stratford MR, Harris AL & Hammond EM 2010 'Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability' Cancer Research 70, (3) 925-935 , DOI PEARL
Hao J-M, Chen J-Z, Sui H-M, Si-Ma X-Q, Li G-Q, Liu C, Li J-L, Ding Y-Q & Li J-M 2010 'A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer' The Journal of Pathology n/a-n/a , DOI PEARL
Biswas S, Troy H, Leek R, Chung Y-L, Li J-L, Raval RR, Turley H, Gatter K, Pezzella F 2010 'Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts' Journal of Oncology 2010, 1-14 , DOI PEARL
Jubb AM, Turley H, Moeller HC, Steers G, Han C, Li J-L, Leek R, Tan EY, Singh B 2009 'Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer' British Journal of Cancer 101, (10) 1749-1757 , DOI PEARL
Martinez JC, Müller MM, Turley H, Steers G, Choteau L, Li J-L, Sainson R, Harris AL, Pezzella F 2009 'Nuclear and membrane expression of the angiogenesis regulator delta-like ligand 4 (DLL4) in normal and malignant human tissues' Histopathology 54, (5) 598-606 , DOI PEARL
Li J-L & Harris AL 2009 'Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications' FRONTIERS IN BIOSCIENCE-LANDMARK 14, 3094-3110 Author Site , DOI PEARL
Harrington LS, Sainson RCA, Williams CK, Taylor JM, Shi W, Li J-L & Harris AL 2008 'Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells' Microvascular Research 75, (2) 144-154 , DOI PEARL
Li J-L, Sainson RCA, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E 2007 'Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo' Cancer Research 67, (23) 11244-11253 , DOI PEARL
Li J-L & Harris AL 2007 'The Potential of New Tumor Endothelium-Specific Markers for the Development of Antivascular Therapy' Cancer Cell 11, (6) 478-481 , DOI PEARL
Patel NS 2006 'Up-Regulation of Endothelial Delta-like 4 Expression Correlates with Vessel Maturation in Bladder Cancer' Clinical Cancer Research 12, (16) 4836-4844 , DOI PEARL
Williams CK 2005 'Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function' Blood 107, (3) 931-939 , DOI PEARL
Patel NS, Li J-L, Generali D, Poulsom R, Cranston DW & Harris AL 2005 'Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function' Cancer Research 65, (19) 8690-8697 , DOI PEARL
Li J-L & Harris AL 2005 'Notch signaling from tumor cells: A new mechanism of angiogenesis' Cancer Cell 8, (1) 1-3 , DOI PEARL
Raval RR, Lau KW, Tran MGB, Sowter HM, Mandriota SJ, Li J-L, Pugh CW, Maxwell PH, Harris AL 2005 'Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma' Molecular and Cellular Biology 25, (13) 5675-5686 , DOI PEARL
Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li J-L, Egli D, Hickson ID & Stagljar I 2004 'Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1' Molecular and Cellular Biology 24, (11) 4710-4719 , DOI PEARL
Braybrooke JP, Li J-L, Wu L, Caple F, Benson FE & Hickson ID 2003 'Functional Interaction between the Bloom's Syndrome Helicase and the RAD51 Paralog, RAD51L3 (RAD51D)' Journal of Biological Chemistry 278, (48) 48357-48366 , DOI PEARL
Li J-L & Cox LS 2003 'Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum' Parasitology International 52, (1) 41-52 , DOI PEARL
Li J-L, Warren AV & Cox LS 2002 'Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum' International Journal for Parasitology 32, (14) 1683-1692 , DOI PEARL
Yang Q, Zhang R, Wang XW, Spillare EA, Linke SP, Subramanian D, Griffith JD, Li JL, Hickson ID 2002 'The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53' Journal of Biological Chemistry 277, (35) 31980-31987 , DOI PEARL
Li J-L, Harrison RJ, Reszka AP, Brosh, RM, Bohr VA, Neidle S & Hickson ID 2001 'Inhibition of the Bloom's and Werner's Syndrome Helicases by G-Quadruplex Interacting Ligands†' Biochemistry 40, (50) 15194-15202 , DOI PEARL
Li J-L & Cox LS 2001 'Identification of an MCM4 homologue expressed specifically in the sexual stage of Plasmodium falciparum' International Journal for Parasitology 31, (11) 1246-1252 , DOI PEARL
Li J-L, Targett GAT & Baker DA 2001 'Primary structure and sexual stage-specific expression of a LAMMER protein kinase of Plasmodium falciparum' International Journal for Parasitology 31, (4) 387-392 , DOI PEARL
Li J-L & Cox LS 2000 'Isolation and characterisation of a cAMP-dependent protein kinase catalytic subunit gene from Plasmodium falciparum' Molecular and Biochemical Parasitology 109, (2) 157-163 , DOI PEARL
Brosh RM, Li J-L, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, Hickson ID & Bohr VA 2000 'Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity' Journal of Biological Chemistry 275, (31) 23500-23508 , DOI PEARL
Karow JK, Constantinou A, Li J-L, West SC & Hickson ID 2000 'The Bloom's syndrome gene product promotes branch migration of Holliday junctions' Proceedings of the National Academy of Sciences 97, (12) 6504-6508 , DOI PEARL
Li G-D, Li J-L, Mugthin M & Ward SA 2000 'Molecular cloning of a gene encoding a 20S proteasome β subunit from Plasmodium falciparum' International Journal for Parasitology 30, (6) 729-733 , DOI PEARL
Li J-L, Baker DA & Cox LS 2000 'Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum' Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1491, (1-3) 341-349 , DOI PEARL
Carucci DJ, Witney AA, Muhia DK, Warhurst DC, Schaap P, Meima M, Li J-L, Taylor MC, Kelly JM 2000 'Guanylyl Cyclase Activity Associated with Putative Bifunctional Integral Membrane Proteins inPlasmodium falciparum' Journal of Biological Chemistry 275, (29) 22147-22156 , DOI PEARL
Baker DA & Li J-L 1999 'A Family of PP2 Phosphatases in Plasmodium falciparum and Parasitic Protozoa: Reply' Parasitology Today 15, (3) 124-124 , DOI PEARL
Li J 1998 'A putative protein serine/threonine phosphatase from Plasmodium falciparum contains a large N-terminal extension and five unique inserts in the catalytic domain' Molecular and Biochemical Parasitology 95, (2) 287-295 , DOI PEARL
Li J-L & Baker DA 1997 'Protein Phosphatase beta, a Putative Type-2A Protein Phosphatase from the Human Malaria Parasite Plasmodium Falciparum' European Journal of Biochemistry 249, (1) 98-106 , DOI PEARL
Li J-L, Robson KJH, Chen J-L, Targett GAT & Baker DA 1996 'Pfmrk, A MO15-Related Protein Kinase from Plasmodium falciparum. Gene Cloning, Sequence, Stage-Specific Expression and Chromosome Localization' European Journal of Biochemistry 241, (3) 805-813 , DOI PEARL
Li J-L, Li Y-J, Chao S, Ouyang M-H & Peng Y-B 1993 'Serum-free medium for long-term growth, freezing, cloning and fusion of myelomas and hybridomas' In Vitro Cellular & Developmental Biology - Animal 29, (2) 87-88 , DOI PEARL
Chapters
Li J 2009 'DNA replication in the human malaria parasite and potential for novel drug development' Molecular Themes in DNA Replication Royal Society of Chemistry PEARL
Conference Papers
Yang J, Ledaki I, Turley H, Gatter KC, Montero J-CM, Li J-L & Harris AL 2009 'Role of Hypoxia-Inducible Factors in Epigenetic Regulation via Histone Demethylases' Wiley 185-197 , DOI PEARL
Hickson ID, Davies SL, Li J-L, Levitt NC, Mohaghegh P, North PS & Wu L 2001 'Role of the Bloom's syndrome helicase in maintenance of genome stability' Portland Press Ltd. 201-204 , DOI PEARL

Links

Ji-Liang Li - Google Scholar Citations

https://www.researchgate.net/profile/Ji-Liang_Li