Professor Simon Jackson
Profiles

Professor Simon Jackson

Associate Head of School / Professor of Environment and Human Health

School of Biomedical Sciences (Faculty of Medicine and Dentistry)

Role

Lead for Biomedical research, PUPSMD 
Assoc. Head (Research), School of Biomedical and Healthcare Sciences, PUPSMD
 

Qualifications

BSc (Hons) Chemistry/Biochemistry, University of Wales (1982),
PhD (University of Wales) (1986) 

Previous positions 

2005 – 2010:  Professor of Molecular Immunology, and Director, Centre for Research in Biomedicine, Faculty of Health and Life  Sciences,  University of the West of England,  Bristol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              

2003-2005:   Director of Research, Department of Medical Microbiology, School of Medicine, Cardiff University,

1994 – 2003: Senior Lecturer, Department of Medical Microbiology, University of Wales College of Medicine,

1993 -1994: Visiting Scientist, Dartmouth Medical School, Dartmouth College, USA

1987- 1993: Lecturer, Department of Medical Microbiology, University of Wales College of Medicine, Cardiff.

Roles on external bodies

Research Consultant for Lonza Bioscience
Member, RSPCA expert working group - models of sepsis 
UK Editor, Innate Immunity

Teaching interests

Teaching Experience

I have extensive experience in running, organising and teaching infection and immunity topics to a range of students including science, medical, dental and other healthcare students. 

Currently I am module leader for BIOM3011 (Public Health Infection Science), BIOM3008 (Current Developments in Biomedical Science), BIOM3026 (Current Developments in Human Bioscience)

Staff serving as external examiners

External examiner for the intermediate MB, School of Medicine, Cardiff University (2010-2013)

External examiner Biomedical Sciences programme, University of Kuwait (2013-2016)

 External advisor, Roehampton University, London

Research interests

My research activities are centred on immunological and inflammatory responses to infection and in particular responses to bacterial lipopolysaccharide (LPS; endotoxin) and related molecular species. Better understanding of such mechanisms will help to develop therapies for severe infectious conditions such as sepsis that carry a high mortality. My group has identified links between lipid modifying enzymes  (lysophospholipid acyltransferases)  that control cell membrane composition and leukocyte signalling responses to LPS and other Toll-like receptor (TLR) ligands. Current work is utilising gene knockdown to identify specific roles for these enzymes in the innate immune response to infection to aid development of new therapeutic and diagnostic approaches. Recently, with collaborators in Birmingham, Nottingham and Cambridge, we have developed novel nano-electrode-cell constructs to identify highly resolved spatial and temporal reactive oxygen (ROS) signalling events in response to LPS in single cells. We are also interested in how inflammatory responses can be amplified by interactions of the signalling pathways with environmental/exogenous molecules and we have established new cell models to explore these effects. These include 3D cell cultures (spheroids) that are more representative of cells and tissues  in vivo . The cell culture models are part of our agenda to reduce or replace animals in research (3Rs). 

Current projects include:

·         The molecular mechanisms by which phospholipid modifying enzymes (lysophospholipid acyltyransferases) regulate innate immune responses and identification of these species as novel therapeutic and diagnostic targets.

·          Measurement and role of reactive oxygen species produced in short time scales and at discreet subcellular sites as triggers of innate immune responses to infectious stimuli.  

Role of LPS-induced inflammatory responses in the pathology of Parkinson's Disease

·         Development of new biomarkers for infectious disease and sepsis and development of novel endotoxin detection systems for clinical and environmental use.

·         Development of 3D cell cultures (spheroids) as novel models for infection and inflammation and as replacements for animals in infection and environmental screening research.

 

Research degrees awarded to supervised students

I have successfully supervised 28 PhD students (currently supervising and co-supervising 5 PhD students); 2 MD students, 5 MPhil, 12 MSc students.

 

Grants & contracts

Recent Grant Funding includes:

'Differentiating cell state using nano-electrochemical sensors for monitoring reactive oxygen species in real time'. (with Dr F. Rawson, Prof. N. Silman) BBSRC iCASE studentship (2014-2018) 

'Moving up a dimension: 3D in vitro models as effective alternatives to live fish studies'.  £629,718 (with Prof. A Jha, Dr S. Owen, Prof W. Purcell) BBSRC (2014-2018)

'Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines'. £91,000 (with Dr G Fejer, Prof N. Silman) MRC/NC3Rs (2013-2014)

PAMP-induced signalling in mammalian trigeminal neurons   (with Dr S. Thompson, Dr J. Bennett.) PhD studentship (2012-2015)

 The role of gut inflammatory responses in the pathogenesis of Parkinson's disease.  (with Drs. C. Carroll, O.Anichtchik) PhD studentship (2013-2016)  

BBSRC China partnering award (with Prof. O Doran, Prof. R Luxton) £21,200 (2010-2013)

Predictive markers of paediatric sepsis (with Prof J. Benger) £15,000, NHS (2012-2013) 

European Union People Marie Curie Action International Research Staff Exchange Scheme   2011-2013 (with Dr O Doran) £75,000

 

A prospective cohort study to investigate the incidence and pathophysiology of Exertional Heat Illness (EHI) in Parachute Regiment trainees (with Dr J Bilzon) £98,000 MOD (2011-2013) 

Oxidative control of LPS- horseshoe crab Factor C interactions. (with Dr M Conway)  £80,000 BBSRC doctoral training studentship (2009-2013)

Key publications are highlighted

Journals
Articles
Langan LM, Harper GM, Owen SF, Purcell WM, Jackson SK & Jha AN 2017 'Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper' Ecotoxicology 26, (8) 1117-1133 , DOI PEARL
Belfield LA, Bennett JH, Abate W & Jackson SK 2017 'Exposure to Porphyromonas gingivalis LPS during macrophage polarisation leads to diminished inflammatory cytokine production' Archives of Oral Biology 81, 41-47 , DOI PEARL
Abate W, Sattar AA, Liu J, Conway ME & Jackson SK 2017 'Evaluation of recombinant factor C assay for the detection of divergent lipopolysaccharide structural species and comparison with Limulus amebocyte lysate-based assays and a human monocyte activity assay' Journal of Medical Microbiology 66, (7) 888-897 , DOI
Hicks JM, Wong ZY, Scurr DJ, Silman N, Jackson SK, Mendes PM, Aylott JW & Rawson FJ 2017 'Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via in Situ Grafting of Aryl Diazonium' Langmuir 33, (20) 4924-4933 , DOI
Baron MG, Mintram KS, Owen SF, Hetheridge MJ, Moody AJ, Purcell WM, Jackson SK & Jha AN 2017 'Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance' PLOS ONE 12, (1) e0168837-e0168837 , DOI PEARL
Williams B, Hayes E, Nasir Z, Rolph C, Jackson S, Khera S, Bennett A, Gladding T, Drew G & Tyrrel S 2017 'The challenges, uncertainties and opportunities of bioaerosol dispersion modelling from open composting facilities' WIT Transactions on Ecology and the Environment 211, 51-59 , DOI
Rawson FJ, Cole MT, Hicks JM, Aylott JW, Milne WI, Collins CM, Jackson SK, Silman NJ & Mendes PM 2016 'Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes' Scientific Reports 6, 37672-37672 , DOI PEARL
Langan LM, Dodd NJF, Owen SF, Purcell WM, Jackson SK & Jha AN 2016 'Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry' PLOS ONE 11, (8) e0160795-e0160795 , DOI PEARL
Langan LM, Dodd NJF, Owen SF, Purcell WM, Jackson SK & Jha AN 2016 'Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry' PLOS ONE 11, (2) e0149492-e0149492 , DOI PEARL
Kanyong P, Hughes G, Pemberton RM, Jackson SK & Hart JP 2016 'Amperometric Screen-Printed Galactose Biosensor for Cell Toxicity Applications' Analytical Letters 49, (2) 236-244 , DOI
Helley MP, Abate W, Jackson SK, Bennett JH & Thompson SWN 2015 'The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons' Neuroscience 310, 686-698 , DOI PEARL
Rawson FJ, Hicks J, Dodd N, Abate W, Garrett DJ, Yip N, Fejer G, Downard AJ, Baronian KHR & Jackson SK 2015 'Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor' ACS Applied Materials & Interfaces 7, (42) 23527-23537 , DOI PEARL
Lilley E, Armstrong R, Clark N, Gray P, Hawkins P, Mason K, López-Salesansky N, Stark A-K, Jackson SK & Thiemermann C 2015 'Refinement of animal models of sepsis and septic shock' Shock 43, (4) 304-316 Author Site , DOI
Alrammah H, Woldie WA, Avent N & Jackson SK 2014 'Overexpression of lysophosphatidylcholine acyltransferase 2 (LPCAT2) up-regulated LPS-induced responses in a murine macrophage' IMMUNOLOGY 143, 104-105 Author Site
Langan L, Dodd N, Owen SF, Jackson S, Purcell WM & Jha A 2014 'Fish cell lines in 3 dimensional (3D) cultures in ecotoxicological studies: is there oxygen in the middle?' MUTAGENESIS 29, (6) 539-540 Author Site
Pemberton RM, Cox T, Tuffin R, Drago GA, Griffiths J, Pittson R, Johnson G, Xu J, Sage IC & Davies R 2014 'Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers' Sensors (Basel) 14, (11) 20519-20532 Author Site , DOI PEARL
Sattar AA, Jackson SK & Bradley G 2014 'The potential of lipopolysaccharide as a real-time biomarker of bacterial contamination in marine bathing water' J Water Health 12, (1) 105-112 Author Site , DOI
Xu J, Patton D, Jackson SK & Purcell WM 2013 'In-vitro maintenance and functionality of primary renal tubules and their application in the study of relative renal toxicity of nephrotoxic drugs' J Pharmacol Toxicol Methods 68, (2) 269-274 Author Site , DOI
Kanyong P, Pemberton RM, Jackson SK & Hart JP 2013 'Development of an amperometric screen-printed galactose biosensor for serum analysis' Anal Biochem 435, (2) 114-119 Author Site , DOI
Pemberton RM, Cox T, Tuffin R, Sage I, Drago GA, Biddle N, Griffiths J, Pittson R, Johnson G & Xu J 2013 'Microfabricated glucose biosensor for culture welloperation' Biosensors and Bioelectronics 42, 668-677 , DOI
Rawson FJ, Yeung CL, Jackson SK & Mendes PM 2013 'Tailoring 3D Single-Walled Carbon Nanotubes Anchored to Indium Tin Oxide for Natural Cellular Uptake and Intracellular Sensing' NANO LETTERS 13, (1) 1-8 Author Site , DOI PEARL
Baron MG, Owen SF, Purcell WM, Jackson SK & Jha AN 2012 '3D spheroidal fish hepatocytes as an alternative in vitro model for environmental toxicology' MUTAGENESIS 27, (6) 800-800 Author Site
Baron MG, Purcell WM, Jackson SK, Owen SF & Jha AN 2012 'Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes' Ecotoxicology 21, (8) 2419-2429 Author Site , DOI
Kanyong P, Pemberton RM, Jackson SK & Hart JP 2012 'Development of a sandwich format, amperometric screen-printed uric acid biosensor for urine analysis' Anal Biochem 428, (1) 39-43 Author Site , DOI
Pankhurst LJ, Deacon LJ, Liu J, Drew GH, Hayes ET, Jackson S, Longhurst PJ, Longhurst JWS, Pollard SJT & Tyrrel SF 2011 'Spatial variations in airborne microorganism and endotoxin concentrations at green waste composting facilities' INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 214, (5) 376-383 Author Site , DOI
Tezera LB, Hampton J, Jackson SK & Davenport V 2011 'Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ' Cell Microbiol 13, (4) 554-568 Author Site , DOI
Liu J, Pankhurst LJ, Deacon LJ, Abate W, Hayes ET, Drew GH, Longhurst PJ, Pollard S, Longhurst J & Tyrrel SF 2011 'Evaluation of inflammatory effects of airborne endotoxin emitted from composting sources' Environ Toxicol Chem 30, (3) 602-606 Author Site , DOI
Liu J, Abate W, Xu J, Corry D, Kaul B & Jackson SK 2011 'Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures' Innate Immun 17, (3) 245-255 Author Site , DOI
Pemberton RM, Xu J, Pittson R, Drago GA, Griffiths J, Jackson SK & Hart JP 2011 'A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture' Biosens Bioelectron 26, (5) 2448-2453 Author Site , DOI
Pemberton RM, Rawson FJ, Xu J, Pittson R, Drago GA, Griffiths J, Jackson SK & Hart JP 2010 'Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins' MICROCHIMICA ACTA 170, (3-4) 321-330 Author Site , DOI
Abate W, Alghaithy AA, Parton J, Jones KP & Jackson SK 2010 'Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains' J Lipid Res 51, (2) 334-344 Author Site , DOI
Rawson FJ, Jackson SK & Hart JP 2010 'VOLTAMMETRIC BEHAVIOR OF DNA AND ITS DERIVATIVES USING SCREEN PRINTED CARBON ELECTRODES AND ITS POSSIBLE APPLICATION IN GENOTOXICITY SCREENING' ANALYTICAL LETTERS 43, (10-11) 1790-1800 Author Site , DOI
Deacon LJ, Pankhurst LJ, Drew GH, Hayes ET, Jackson S, Longhurst PJ, Longhurst JWS, Liu J, Pollard SJT & Tyrrel SF 2009 'Particle size distribution of airborne Aspergillus fumigatus spores emitted from compost using membrane filtration' ATMOSPHERIC ENVIRONMENT 43, (35) 5698-5701 Author Site , DOI
Xu J & Jackson SK 2009 'Current considerations for the effective safety evaluation of drugs in vitro' Mini Rev Med Chem 9, (7) 861-868 Author Site
Pemberton RM, Xu J, Pittson R, Biddle N, Drago GA, Jackson SK & Hart JP 2009 'Application of screen-printed microband biosensors to end-point measurements of glucose and cell numbers in HepG2 cell culture' Anal Biochem 385, (2) 334-341 Author Site , DOI
Davison GW, Ashton T, George L, Young IS, McEneny J, Davies B, Jackson SK, Peters JR & Bailey DM 2008 'Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial' DIABETOLOGIA 51, (11) 2049-2059 Author Site , DOI
Bazou D, Coakley WT, Hayes AJ & Jackson SK 2008 'Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap' Toxicol In Vitro 22, (5) 1321-1331 Author Site , DOI
Jackson SK, Abate W & Tonks AJ 2008 'Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery' Pharmacol Ther 119, (1) 104-114 Author Site , DOI
Jackson SK, Abate W, Parton J, Jones S & Harwood JL 2008 'Lysophospholipid metabolism facilitates Toll-like receptor 4 membrane translocation to regulate the inflammatory response' J Leukoc Biol 84, (1) 86-92 Author Site , DOI
Morris RHK, Tonks AJ, Jones KP, Ahluwalia MK, Thomas AW, Tonks A & Jackson SK 2008 'DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB' Biochem Biophys Res Commun 370, (1) 174-178 Author Site , DOI
Khanolkar MP, Morris RHK, Thomas AW, Bolusani H, Roberts AW, Geen J, Jackson SK & Evans LM 2008 'Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus—An effect probably mediated by direct platelet PPARγ activation' Atherosclerosis 197, (2) 718-724 , DOI
Liu J, Kuznetsova LA, Edwards GO, Xu J, Ma M, Purcell WM, Jackson SK & Coakley WT 2007 'Functional three-dimensional HepG2 aggregate cultures generated from an ultrasound trap: comparison with HepG2 spheroids' J Cell Biochem 102, (5) 1180-1189 Author Site , DOI
Bamford S, Ryley H & Jackson SK 2007 'Highly purified lipopolysaccharides from Burkholderia cepacia complex clinical isolates induce inflammatory cytokine responses via TLR4-mediated MAPK signalling pathways and activation of NFkappaB' Cell Microbiol 9, (2) 532-543 Author Site , DOI
Bailey DM, Lawrenson L, McEneny J, Young IS, James PE, Jackson SK, Henry RR, Mathieu-Costello O, McCord JM & Richardson RS 2007 'Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle' FREE RADICAL RESEARCH 41, (2) 182-190 Author Site , DOI
Henriques A, Jackson S, Cooper R & Burton N 2006 'Free radical production and quenching in honeys with wound healing potential' J Antimicrob Chemother 58, (4) 773-777 Author Site , DOI
Anderson RA, Evans LM, Ellis GR, Khan N, Morris K, Jackson SK, Rees A, Lewis MJ & Frenneaux MP 2006 'Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes' DIABETIC MEDICINE 23, (3) 258-264 Author Site , DOI
Robinson GM, Jackson SK, Salisbury VC & Nelson SM 2006 'The use of lux genes for monitoring the uptake of Pseudomonas aeruginosa by respiratory epithelial cells' LUMINESCENCE 21, (5) 289-289 Author Site
Anderson RA, Ellis GR, Evans LM, Morris K, Chirkov YY, Horowitz JD, Jackson SK, Rees A, Lewis MJ & Frenneaux MP 2005 'Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes' Diab Vasc Dis Res 2, (2) 88-93 Author Site , DOI
Neville NT, Parton J, Harwood JL & Jackson SK 2005 'The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma' Biochim Biophys Acta 1733, (2-3) 232-238 Author Site , DOI
Tonks A, Parton J, Tonks AJ, Morris RHK, Finall A, Jones KP & Jackson SK 2005 'Surfactant phospholipid DPPC downregulates monocyte respiratory burst via modulation of PKC' Am J Physiol Lung Cell Mol Physiol 288, (6) L1070-L1080 Author Site , DOI
Bailey DM, Ainslie PN, Jackson SK, Richardson RS & Ghatei M 2004 'Evidence against redox regulation of energy homoeostasis in humans at high altitude' CLINICAL SCIENCE 107, (6) 589-600 Author Site , DOI
Alam TM, Celina M, Collier JP, Currier BH, Currier JH, Jackson SK, Kuethe DO & Timmins GS 2004 'G-irradiation of ultrahigh-molecular-weight polyethylene: Electron paramagnetic resonance and nuclear magnetic resonance spectroscopy and imaging studies of the mechanism of subsurface oxidation' JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 42, (23) 5929-5941 Author Site , DOI
James PE, Thomas MP & Jackson SK 2004 'Tissue oxygenation in sepsis; new insights fromin vivo EPR' NMR in Biomedicine 17, (5) 319-326 , DOI
Anderson RA, Ellis GR, Chirkov YY, Holmes AS, Payne N, Blackman DJ, Jackson SK, Lewis MJ, Horowitz JD & Frenneaux MP 2004 'Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure' Eur J Heart Fail 6, (1) 47-54 Author Site , DOI
Jackson SK, Thomas MP, Smith S, Madhani M, Rogers SC & James PE 2004 'In vivo EPR spectroscopy: biomedical and potential diagnostic applications' Faraday Discuss 126, 103-117 Author Site
Jackson SK & Parton J 2004 'Lysophospholipid acyltransferases in monocyte inflammatory responses and sepsis' Immunobiology 209, (1-2) 31-38 Author Site , DOI
Collier JP, Currier BH, Kennedy FE, Currier JH, Timmins GS, Jackson SK & Brewer RL 2003 'Comparison of cross-linked polyethylene materials for orthopaedic applications' CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (414) 289-304 Author Site , DOI
Ashton T, Young IS, Davison GW, Rowlands CC, McEneny J, Van Blerk C, Jones E, Peters JR & Jackson SK 2003 'Exercise-induced endotoxemia: the effect of ascorbic acid supplementation' Free Radic Biol Med 35, (3) 284-291 Author Site
Schmid B, Finnen MJ, Harwood JL & Jackson SK 2003 'Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide' Eur J Biochem 270, (13) 2782-2788 Author Site
Tonks AJ, Tonks A, Morris RHK, Jones KP & Jackson SK 2003 'Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine' J Leukoc Biol 74, (1) 95-101 Author Site
James PE, Parton J, Jackson SK & Frenneaux MP 2003 'Oxygen indirectly regulates nitric oxide availability' Adv Exp Med Biol 510, 139-143 Author Site
Thomas MP, Jackson SK & James PE 2003 'Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry' Adv Exp Med Biol 510, 205-211 Author Site
Madhani M, Barchowsky A, Klei L, Ross CR, Jackson SK, Swartz HM & James PE 2002 'Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock' Biochim Biophys Acta 1588, (3) 232-240 Author Site
Davison GW, George L, Jackson SK, Young IS, Davies B, Bailey DM, Peters JR & Ashton T 2002 'Exercise, free radicals, and lipid peroxidation in type 1 diabetes mellitus' FREE RADICAL BIOLOGY AND MEDICINE 33, (11) 1543-1551 Author Site , DOI
Ellis GR, Nightingale AK, Blackman DJ, Anderson RA, Mumford C, Timmins G, Lang D, Jackson SK, Penney MD & Lewis MJ 2002 'Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress' EUROPEAN JOURNAL OF HEART FAILURE 4, (2) 193-199 Author Site , DOI
Jackson SK, Liu KJ, Liu M & Timmins GS 2002 'Detection and removal of contaminating hydroxylamines from the spin trap DEPMPO, and re-evaluation of its use to indicate nitrone radical cation formation and SN1 reactions' Free Radical Biology and Medicine 32, (3) 228-232 , DOI
James PE, Madhani M, Roebuck W, Jackson SK & Swartz HM 2002 'Endotoxin-induced liver hypoxia: Defective oxygen delivery versus oxygen consumption' NITRIC OXIDE-BIOLOGY AND CHEMISTRY 6, (1) 18-28 Author Site , DOI
Timmins GS, Robb FJ, Wilmot CM, Jackson SK & Swartz HM 2001 'Firefly flashing is controlled by gating oxygen to light-emitting cells' Journal of Experimental Biology 204, (16) 2795-2801
Tonks A, Price AJ, Morris RHK, Jones KP & Jackson SK 2001 'Pulmonary surfactant and DPPC inhibit superoxide production in monocytes' BLOOD 98, (11) 227A-227A Author Site
Price AJ, Tonks A, Morris RHK, Jones KP, Jackson SK & Mills KI 2001 'Synthesis of platelet-activating factor (PAF) in monocytic cells is inhibited by dipalmitoyl phosphatidylcholine via inhibition of enzymes of the remodelling pathway' BLOOD 98, (11) 226A-226A Author Site
Anderson R, Khan N, Evans M, Ellis G, Jackson SK, Lewis MJ, Rees A & Frenneaux MP 2001 'There is prolonged post-prandial lipaemia-induced endothelial dysfunction in type 2 diabetes and is reversible with vitamin C therapy' EUROPEAN HEART JOURNAL 22, 157-157 Author Site
Timmins GS, Robb FJ, Wilmot CM, Jackson SK & Swartz HM 2001 'Firefly flashing is controlled by gating oxygen to light-emitting cells' J Exp Biol 204, (Pt 16) 2795-2801 Author Site
Nightingale AK, James PP, Morris-Thurgood J, Harrold F, Tong R, Jackson SK, Cockcroft JR & Frenneaux MP 2001 'Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model' American Journal of Physiology - Heart and Circulatory Physiology 280, (3 49-3)
Ellis GR, Anderson RA, Chirkov YY, Morris-Thurgood J, Jackson SK, Lewis MJ, Horowitz JD & Frenneaux MP 2001 'Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure' J Cardiovasc Pharmacol 37, (5) 564-570 Author Site
Tonks A, Morris RH, Price AJ, Thomas AW, Jones KP & Jackson SK 2001 'Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases' Clin Exp Immunol 124, (1) 86-94 Author Site
Timmins GS, Jackson SK & Swartz HM 2001 'The evolution of bioluminescent oxygen consumption as an ancient oxygen detoxification mechanism' J Mol Evol 52, (4) 321-332 Author Site , DOI
Jackson SK, Madhani M, Thomas M, Timmins GS & James PE 2001 'Applications of in vivo electron paramagnetic resonance (EPR) spectroscopy: measurements of pO2 and NO in endotoxin shock' Toxicol Lett 120, (1-3) 253-257 Author Site
Nightingale AK, James PP, Morris-Thurgood J, Harrold F, Tong R, Jackson SK, Cockcroft JR & Frenneaux MP 2001 'Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model' Am J Physiol Heart Circ Physiol 280, (3) H1334-H1339 Author Site , DOI
Flanagan PG, Jackson SK & Findlay G 2001 'Diagnosis of Gram negative, ventilator associated pneumonia by assaying endotoxin in bronchial lavage fluid' JOURNAL OF CLINICAL PATHOLOGY 54, (2) 107-110 Author Site , DOI
Anderson RA, Evans ML, Ellis GR, Graham J, Morris K, Jackson SK, Lewis MJ, Rees A & Frenneaux MP 2001 'The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes' Atherosclerosis 154, (2) 475-483 Author Site
Ellis GR, Anderson RA, Lang D, Blackman DJ, Morris R, Morris-Thurgood J, McDowell IF, Jackson SK, Lewis MJ & Frenneaux MP 2000 'Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy' Journal of the American College of Cardiology 36, (5) 1474-1482 , DOI
Morris RH, Price A, Tonks A, Jackson S & Jones K 2000 'PROSTAGLANDIN E2AND TUMOUR NECROSIS FACTOR-α RELEASE BY MONOCYTES ARE MODULATED BY PHOSPHOLIPIDS' Cytokine 12, (11) 1717-1719 , DOI
Ellis GR, Nightingale AK, Blackman DJ, Anderson RA, Lang D, Timmins G, Jackson SK, Lewis MJ & Frenneaux MP 2000 'Combination therapy with an angiotensin II antagonist and angiotensin converting enzyme inhibitors have no effect on endothelial function and oxidative stress in chronic heart failure' CIRCULATION 102, (18) 535-535 Author Site
Anderson RA, Gapper P, Khan N, Ellis GR, Chirkov YY, Horowitz JD, Jackson SK, Lewis MJ, Rees A & Frenneaux MP 2000 'Fasting and postprandial platelet nitrate responsiveness in type 2 diabetes' CIRCULATION 102, (18) 334-334 Author Site
Anderson RA, Ellis GR, Chirkov YY, Blackman DJ, Jackson SK, Lewis MJ, Horowitz JD & Frenneaux MP 2000 'Primary nitric oxide resistance and oxidative stress in patients with chronic heart failure' Heart 83, (SUPPL. 1)
Evans M, Anderson RA, Graham J, Ellis GR, Morris K, Davies S, Jackson SK, Lewis MJ, Frenneaux MP & Rees A 2000 'Ciprofibrate Therapy Improves Endothelial Function and Reduces Postprandial Lipemia and Oxidative Stress in Type 2 Diabetes Mellitus' Circulation 101, (15) 1773-1779 , DOI
Evans L, Davies J, Anderson R, Ellis G, Jackson S, Lewis M, Frenneaux M, Rees A & Scanlon M 2000 'The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency' European Journal of Endocrinology 142, (3) 254-262 , DOI
Ashton T, Young IS, Peters JR, Jones E, Jackson SK, Davies B & Rowlands CC 1999 'Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study' J Appl Physiol (1985) 87, (6) 2032-2036 Author Site , DOI
Glover RE, Smith RR, Jones MV, Jackson SK & Rowlands CC 1999 'An EPR investigation of surfactant action on bacterial membranes' FEMS Microbiology Letters 177, (1) 57-62 , DOI
Anderson RA, Evans LM, Ellis GR, Jackson SK, Lewis MJ, Rees A & Frenneaux MP 1999 'NIDDM subjects exhibit an increase in lipid peroxidation and augmented endothelial dysfunction in response to post-prandial lipaemia' Heart 81, (SUPPL. 1)
Ellis GR, Anderson RA, Blackman DJ, Morris-Thurgood J, Jackson SK, Lewis MJ & Frenneaux MP 1999 'Oxidative stress is greater in patients with chronic heart failure due to coronary artery disease' Heart 81, (SUPPL. 1)
Naka KK, Goodfellow J, Ellis GR, Anderson R, Tweddel AC, Dunstan F, Jackson S & Frenneaux M 1999 'Vitamin C improves arterial distensibility following maximal exercise in healthy subjects' Heart 81, (SUPPL. 1)
Zughaier SM, Ryley HC & Jackson SK 1999 'Lipopolysaccharide (LPS) from Burkholderia cepacia is more active than LPS from Pseudomonas aeruginosa and Stenotrophomonas maltophilia in stimulating tumor necrosis factor alpha from human monocytes' Infect Immun 67, (3) 1505-1507 Author Site
Zughaier SM, Ryley HC & Jackson SK 1999 'A melanin pigment purified from an epidemic strain of Burkholderia cepacia attenuates monocyte respiratory burst activity by scavenging superoxide anion' Infect Immun 67, (2) 908-913 Author Site
Ashton T, Rowlands CC, Jones E, Young IS, Jackson SK, Davies B & Peters JR 1998 'Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise' European Journal of Applied Physiology 77, (6) 498-502 , DOI
Ellis GR, Anderson RA, Glover R, Jackson SK, Lewis MJ & Frenneaux MP 1998 'Free radical levels are increased in venous blood in dilated cardiomyopathy' Heart 79, (SUPPL. 1)
Ellis GR, Anderson RA, Lang D, Jackson SK, Frenneaux MP & Lewis MJ 1998 'The ability of neutrophils to generate superoxide anions is increased in chronic heart failure and correlates with NYHA status' Heart 79, (SUPPL. 1)
Darke BM, Jackson SK, Hanna SM & Fox JD 1998 'Detection of human TNF-α mRNA by NASBA™' Journal of Immunological Methods 212, (1) 19-28 , DOI
Jackson SK 1997 'Role of lipid metabolites in the signalling and activation of macrophage cells by lipopolysaccharide' Progress in Lipid Research 36, (4) 227-244 , DOI
Kelly DR, Jones S, Adigun JO, Koh KS, Hibbs DE, Hursthouse MB & Jackson SK 1997 'The addition of nitric oxide to 1,5-dimethylhexa-2,4-diene; X-ray crystal structure determination of the major product, (E)-2,5-dimethyl-2,5-dinitrohex-3-ene' Tetrahedron 53, (50) 17221-17234 , DOI
Kelly DR, Jones S, Adigun JO, Koh KSV & Jackson SK 1997 'The addition of nitric oxide to 2,5-dimethyl-hexa-2,4-diene gives nitrogen dioxide adducts' Tetrahedron Letters 38, (7) 1245-1248 , DOI
Rahmati-Bahram A 1997 'Effect of temperature on aminoglycoside binding sites in Stenotrophomonas maltophilia' Journal of Antimicrobial Chemotherapy 39, (1) 19-24 , DOI
James PE, Bacic G, Grinberg OY, Goda F, Dunn JF, Jackson SK & Swartz HM 1996 'Endotoxin-induced changes in intrarenal pO2, measured by in vivo electron paramagnetic resonance oximetry and magnetic resonance imaging' Free Radical Biology and Medicine 21, (1) 25-34 , DOI
Glover RE, Mile B, Rowlands CC & Jackson SK 1996 'Lipopolysaccharide decreases oxygen consumption by Mono Mac 6 cells; an electron paramagnetic resonance oximetry study' Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1310, (1) 5-9 , DOI
Maru A & Jackson SK 1996 'Opposite effects of interleukin-4 and interleukin-10 on nitric oxide production in murine macrophages' Mediators of Inflammation 5, (2) 110-112 , DOI
Rahmati-Bahram A, Magee JT & Jackson SK 1996 'Temperature-dependent aminoglycoside resistance in Stenotrophomonas (Xanthomonas) maltophilia; alterations in protein and lipopolysaccharide with growth temperature' Journal of Antimicrobial Chemotherapy 37, (4) 665-676 , DOI
Darmani H, Harwood JL & Jackson SK 1995 'Differential effects of interferon-gamma and -beta on fatty acid turnover, lipid bilayer fluidity and TNF-alpha release in murine macrophage J774.2 cells' Int J Exp Pathol 76, (5) 331-337 Author Site
James PE, Jackson SK, Grinberg OY & Swartz HM 1995 'The effects of endotoxin on oxygen consumption of various cell types in vitro: An EPR oximetry study' Free Radical Biology and Medicine 18, (4) 641-647 , DOI
Fegan C, Jackson SK & Whittaker JA 1995 'Antigenaemia during acute graft versus host disease' Journal of Clinical Pathology 48, (2) 105-109 , DOI
Rahmati-Bahram A, Magee JT & Jackson SK 1995 'Growth temperature-dependent variation of cell envelope lipids and antibiotic susceptibility in Stenotrophomonas (Xanthomonas) maltophilia' Journal of Antimicrobial Chemotherapy 36, (2) 317-326 , DOI
Darmani H, Parton J, Harwood JL & Jackson SK 1994 'Interferon-gamma and polyunsaturated fatty acids increase the binding of lipopolysaccharide to macrophages' Int J Exp Pathol 75, (5) 363-368 Author Site
Magee JT, Randle EA, Gray SJ & Jackson SK 1994 'Pyrolysis mass spectrometry characterisation and numerical taxonomy ofAeromonas spp' Antonie van Leeuwenhoek 64, (3-4) 315-323 , DOI
DARMANI H, HARWOOD JL & JACKSON SK 1993 'Effect of Interferon-γ on Membrane Conformation in the Macrophage-Like Cell Line P388D' Journal of Interferon Research 13, (6) 427-431 , DOI
Darmani H, Harwood JL & Jackson SK 1993 'Interferon-γ-Stimulated Uptake and Turnover of Linoleate and Arachidonate in Macrophages: A Possible Pathway for Hypersensitivity to Endotoxin' Cellular Immunology 152, (1) 59-71 , DOI
JACKSON SK, PARTON J, BARNES RA, POYNTON CH & FEGAN C 1993 'Effect of IgM-enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti-endotoxin antibodies in bone marrow transplantation' European Journal of Clinical Investigation 23, (9) 540-545 , DOI
Barnes RA & Jackson SK 1993 'Unusual infections and novel therapeutic strategies' Current Opinion in Infectious Diseases 6, (3) 427-431
Jackson SK, Darmani H, Stark JM & Harwood JL 1992 'Interferon-gamma increases macrophage phospholipid polyunsaturation: a possible mechanism of endotoxin sensitivity' Int J Exp Pathol 73, (6) 783-791 Author Site
James PE, Jackson SK, Rowlands CC & Mile B 1992 'Molecular interactions between bacterial endotoxins and mammalian cells. A spin-label study' Journal of the Chemical Society, Perkin Transactions 2 (9) 1503-1508
James PE, Jackson SK, Rowlands CC & Mile B 1992 'Binding of spin-labelled analogues of endotoxin to serum proteins' Applied Magnetic Resonance 3, (5) 815-825 , DOI
Jackson SK, James PE, Rowlands CC & Mile B 1992 'Binding of endotoxin to macrophages; interactions of spin-labelled saccharide residues' Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1135, (2) 165-170 , DOI
Poynton CH, Jackson S, Fegan C, Barnes RA & Whittaker JA 1992 'Use of IgM enriched intravenous immunoglobulin (Pentaglobin) in bone marrow transplantation' Bone Marrow Transplant 9, (6) 451-457 Author Site
Stark JM & Jackson SK 1990 'Sensitivity to endotoxin is induced by increased membrane fatty-acid unsaturation and oxidant stress' Journal of Medical Microbiology 32, (4) 217-221 , DOI
Jackson SK, Parton J, Shortland G, Stark JM & Thompson EN 1990 'Serum immunoglobulins to endotoxin core glycolipid: acute leukaemia and other cancers' Archives of Disease in Childhood 65, (7) 771-773 , DOI
Jackson SK, Parton J, Shortland G, Stark JM & Thompson EN 1990 'Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations' Archives of Disease in Childhood 65, (7) 768-770 , DOI
Stark JM, Jackson SK, Taylor S, Davies I & Harwood JL 1990 'The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice' Experientia 46, (5) 472-474 , DOI
Lunec J, Griffiths H, Harman D, Evans JC, Jackson SK, Murphy ME, Sies H & Gutteridge JMC 1990 'Free radicals in biotechnology and medicine' Analytical Proceedings 27, (8) 212-212 , DOI
Jackson SK, Stark JM, Taylor S & Harwood JL 1989 'Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin' Br J Exp Pathol 70, (4) 435-441 Author Site
Jackson SK, James PE, Rowlands CC & Evans JC 1989 'Effects of E. Coli 0111.B4 Lipopolysaccharide on Spin-Labelled Murine Macrophage and Hepatocyte Membranes' Free Radical Research Communications 8, (1) 47-53 , DOI
Jackson SK, Stark J, Rowlands CC & Evans JC 1989 'Electron spin resonance detection of oxygen-centred radicals in murine macrophages stimulated with bacterial endotoxin' Free Radical Biology and Medicine 7, (2) 165-170 , DOI
Jackson SK, Stark JM, Rowlands CC & Evans JC 1988 'Is gram-negative shock a free-radical-mediated condition?' Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases 84, (10) 3243-3243 , DOI
Stark JM, Jackson SK, Woodhead B & Ryley HC 1987 'Tissue oxidation after endotoxin' Bioelectrochemistry and Bioenergetics 18, (1-3) 301-306 , DOI
Matthews N, Neale ML, Jackson SK & Stark JM 1987 'Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism' Immunology 62, (1) 153-155 Author Site
Evans JC, Jackson SK, Rowlands CC & Barratt MD 1986 'Covalent binding of human serum albumin and ovalbumin by chloramine-T and chemical modification of the proteins' Analytica Chimica Acta 186, 319-323 , DOI
Evans JC, Rao KRN, Jackson SK, Rowlands CC & Barratt MD 1985 'Identification of radicals spin-trapped in autoxidized linoleic acids: A high performance liquid chromatography and electron spin resonance study' Journal of High Resolution Chromatography 8, (12) 829-830 , DOI
Evans JC, Jackson SK, Rowlands CC & Barratt MD 1985 'ENDOR, triple resonance and ESR studies of spin-trapped radicals in autoxidized linoleic acid and its deuterated derivatives' Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 835, (3) 421-425 , DOI
Evans JC, Jackson SK, Rowlands CC & Barratt MD 1985 'An electron spin resonance study of radicals from chloramine-t-1. Spin trapping of radicals produced in acid media' Tetrahedron 41, (22) 5191-5194 , DOI
Evans JC, Jackson SK, Rowlands CC & Barratt MD 1985 'An electron spin resonance study of radicals from chloramine-T-2. Spin trapping of photolysis products of chloramine-t at alkaline pH' Tetrahedron 41, (22) 5195-5200 , DOI
Evans JC, Jackson SK, Rowlands CC & Barratt MD 1984 'Endor and ESR studies of spin-trapped radicals in autoxidized unsaturated fatty acid methyl esters' Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 792, (2) 239-242 , DOI
Conference Papers
Wood C, Logue C, Silman N, Jackson S & Fejer G 2016 'A novel alveolar-like macrophage to study influenza A infection in vitro' 438-438
Khera S, Sharma V, Fejer G, Tyrrel S, Bennett A & Jackson S 2016 'Development and characterization of a novel cell-based biosensor for screening of inflammatory agents in bioaerosols' 1176-1176
Abate W, Sharma V & Jackson S 2016 'Lysophosphatidylcholine acyltransferase (LPCAT) 2 regulates macrophage inflammatory responses through acylation of key metabolic proteins' 837-837
Koopman H, Jackson S, Anichtchik O & Carroll C 2015 'LPS INDUCES AGGREGATION OF α-SYNUCLEIN IN MONOCYTES' e4.188-e4 , DOI
Abate W & Jackson S 2015 'Lysophosphatidylcholine Acyltransferase (LPCAT)-2 Co-localises with TLR4 and Regulates Macrophage Inflammatory Gene expression in Response to LPS'
Tezera LB, Page K, Jackson S & Davenport V 2010 'Neisseria lactamica attenuates TLR 1/2 - induced cytokine responses in nasopharyngeal epithelial cells using PPAR-gamma' 54-54
Deacon L, Pankhurst L, Liu J, Drew GH, Hayes ET, Jackson S, Longhurst J, Longhurst P, Pollard S & Tyrrel S 2009 'Endotoxin emissions from commercial composting activities' , DOI PEARL
Pankhurst LJ, Deacon LJ, Liu J, Drew GH, Hayes ET, Jackson S, Longhurst PJ, Longhurst JWS, Pollard SJT & Tyrrel SF 2009 'Microbial and endotoxin emission from composting facilities: characterisation of release and dispersal patterns' 163-+ , DOI
Robinson GM, Jackson SK, Salisbury VC & Nelson SM 2007 'THE USE OF LUXGENES FOR MONITORING UPTAKE OF PSEUDOMONAS AERUGINOSA BY RESPIRATORY EPITHELIAL CELLS' 127-130 , DOI
Khanolkar M, Thomas AW, Jackson SK, Roberts A, George L, Geen J, Rees A, Morris RHK & Evans LM 2005 'Vascular benefits of rosigltazone and metformin compared with sulphonylurea and metformin combination therapy' S4-S4
Morris-Stiff G, Hullin D, Oleesky D, Smith S, Jackson S, James P, Baines M, Shenkin R, Sayes R & Schwalbe E 2004 'Oxidative stress, the matrix and the pathogenesis of abdominal aortic aneurysms (AAAs)' 1233-1233
Bailey DM, Lawrenson L, James PE, Jackson SK, Henry R & Richardson RS 2004 'EPR spectroscopic detection of semiquinone radicals in human skeletal muscle; - Focus on exercise and age' S270-S270
Thomas MP, Jackson SK & James PE 2003 'Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO(2) in a mouse model measured by EPR spectrometry' 257-263
Maclean RM, Bowen D, Jackson S, Giddings J & Collins PW 2002 'Endothelial cell adhesion molecules and their influence on monocyte tissue factor expression' 266A-266A
Tonks AJ, Tonks A, Morris RHK, Parton J, Jones KP & Jackson SK 2002 'Phospholipids modulate arachidonic acid metabolism in monocytic cells' 44B-45B
Tonks A, Tonks AJ, Mills KI, Morris RHK, Parton J, Jones KP & Jackson SK 2002 'Pulmonary surfactant phospholipids selectively modulate inflammatory mediator production in monocytes and macrophages' 457A-457A
Tonks A, Jones KP & Jackson SK 1999 'Phospholipid modulation of monocyte oxidative activity measured by luminol-enhanced chemiluminescence' S147-S147 , DOI
NEVILLE NT, JACKSON SK & HARWOOD JL 1997 'The effects of inflammatory cytokines on acyl coenzymeA-dependent acyltransferase' 496S-496S , DOI
Jackson SK, James PE & Swartz HM 1997 'Effect of lipopolysaccharide on intra-phagosomal oxygen concentration as measured by EPR oximetry' United States 613-620

Other academic activities

Editorial Board, Innate Immunity
Expert panel member, models of sepsis research, RSPCA