- B426, Portland Square, Drake Circus, Plymouth, PL4 8AA
- +44 1752 584896
- simon.jackson@plymouth.ac.uk
Profiles
Professor Simon Jackson
Professor
School of Biomedical Sciences (Faculty of Health)
Biography
Biography
Lead for Biomedical research, PUPSMD
Assoc. Head (Research), School of Biomedical and Healthcare Sciences, PUPSMD
Qualifications
BSc (Hons) Chemistry/Biochemistry, University of Wales (1982),
PhD (University of Wales) (1986)
| Previous positions 2003-2005: Director of Research, Department of Medical Microbiology, School of Medicine, Cardiff University, 1994 – 2003: Senior Lecturer, Department of Medical Microbiology, University of Wales College of Medicine, 1993 -1994: Visiting Scientist, Dartmouth Medical School, Dartmouth College, USA 1987- 1993: Lecturer, Department of Medical Microbiology, University of Wales College of Medicine, Cardiff. |
Roles on external bodies
Research Consultant for Lonza Bioscience
Member, RSPCA expert working group - models of sepsis
UK Editor, Innate Immunity
Teaching
Teaching
Teaching interests
Teaching Experience
I have extensive experience in running, organising and teaching infection and immunity topics to a range of students including science, medical, dental and other healthcare students.
Currently I am module leader for BIOM3011 (Public Health Infection Science), BIOM3008 (Current Developments in Biomedical Science), BIOM3026 (Current Developments in Human Bioscience)
Staff serving as external examiners
External examiner for the intermediate MB, School of Medicine, Cardiff University (2010-2013)
External examiner Biomedical Sciences programme, University of Kuwait (2013-2016)
External advisor, Roehampton University, London
Research
Research
Research interests
My research activities are centred on immunological and inflammatory responses to infection and in particular responses to bacterial lipopolysaccharide (LPS; endotoxin) and related molecular species. Better understanding of such mechanisms will help to develop therapies for severe infectious conditions such as sepsis that carry a high mortality. My group has identified links between lipid modifying enzymes (lysophospholipid acyltransferases) that control cell membrane composition and leukocyte signalling responses to LPS and other Toll-like receptor (TLR) ligands. Current work is utilising gene knockdown to identify specific roles for these enzymes in the innate immune response to infection to aid development of new therapeutic and diagnostic approaches. Recently, with collaborators in Birmingham, Nottingham and Cambridge, we have developed novel nano-electrode-cell constructs to identify highly resolved spatial and temporal reactive oxygen (ROS) signalling events in response to LPS in single cells. We are also interested in how inflammatory responses can be amplified by interactions of the signalling pathways with environmental/exogenous molecules and we have established new cell models to explore these effects. These include 3D cell cultures (spheroids) that are more representative of cells and tissues in vivo . The cell culture models are part of our agenda to reduce or replace animals in research (3Rs).
Current projects include:
· The molecular mechanisms by which phospholipid modifying enzymes (lysophospholipid acyltyransferases) regulate innate immune responses and identification of these species as novel therapeutic and diagnostic targets.
· Measurement and role of reactive oxygen species produced in short time scales and at discreet subcellular sites as triggers of innate immune responses to infectious stimuli.
Role of LPS-induced inflammatory responses in the pathology of Parkinson's Disease
· Development of new biomarkers for infectious disease and sepsis and development of novel endotoxin detection systems for clinical and environmental use.
· Development of 3D cell cultures (spheroids) as novel models for infection and inflammation and as replacements for animals in infection and environmental screening research.
Research degrees awarded to supervised students
I have successfully supervised 28 PhD students (currently supervising and co-supervising 5 PhD students); 2 MD students, 5 MPhil, 12 MSc students.
Grants & contracts
Recent Grant Funding includes:
'Differentiating cell state using nano-electrochemical sensors for monitoring reactive oxygen species in real time'. (with Dr F. Rawson, Prof. N. Silman) BBSRC iCASE studentship (2014-2018)
'Moving up a dimension: 3D in vitro models as effective alternatives to live fish studies'. £629,718 (with Prof. A Jha, Dr S. Owen, Prof W. Purcell) BBSRC (2014-2018)
'Establishment of non-transformed, continuously growing, alternatively activated mouse macrophage cell lines'. £91,000 (with Dr G Fejer, Prof N. Silman) MRC/NC3Rs (2013-2014)
PAMP-induced signalling in mammalian trigeminal neurons (with Dr S. Thompson, Dr J. Bennett.) PhD studentship (2012-2015)
The role of gut inflammatory responses in the pathogenesis of Parkinson's disease. (with Drs. C. Carroll, O.Anichtchik) PhD studentship (2013-2016)
BBSRC China partnering award (with Prof. O Doran, Prof. R Luxton) £21,200 (2010-2013)
Predictive markers of paediatric sepsis (with Prof J. Benger) £15,000, NHS (2012-2013)
European Union People Marie Curie Action International Research Staff Exchange Scheme 2011-2013 (with Dr O Doran) £75,000
A prospective cohort study to investigate the incidence and pathophysiology of Exertional Heat Illness (EHI) in Parachute Regiment trainees (with Dr J Bilzon) £98,000 MOD (2011-2013)
Oxidative control of LPS- horseshoe crab Factor C interactions. (with Dr M Conway) £80,000 BBSRC doctoral training studentship (2009-2013)
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2023) 'Air quality and mental health: evidence, challenges and future directions' BJPsych Open 9, (4) , DOI Open access
(2022) 'Endotoxin as a Marker for Water Quality' International Journal of Environmental Research and Public Health 19, (24) 16528-16528 , DOI Open access
(2022) 'Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia' Metabolites 12, (8) , DOI Open access
(2022) 'Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells' Bioscience Reports , DOI Open access
(2022) 'Micro and nano-plastics, a threat to human health?' EMERGING TOPICS IN LIFE SCIENCES 6, (4) 411-422 , DOI
(2020) 'Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs' Clinical Science 134, (13) 1715-1734 , DOI Open access
(2020) 'Mass transport of lipopolysaccharide induced H2O2 detected by an intracellular carbon nanoelectrode sensor' Bioelectrochemistry 135, 107547-107547 , DOI Open access
(2020) 'Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing' PLOS Neglected Tropical Diseases 14, (1) e0007897-e0007897 , DOI Open access
(2019) 'Evaluation of the proinflammatory effects of contaminated bathing water' Journal of Toxicology and Environmental Health, Part A 82, (20) 1076-1087 , DOI
(2019) 'Real-time bacterial detection with an intracellular ROS sensing platform' Biosensors and Bioelectronics 141, 111430-111430 , DOI
(2018) 'Subgingival lipid A profile and endotoxin activity in periodontal health and disease' Clinical Oral Investigations , DOI Open access
(2018) 'A Controlled Study on the Characterisation of Bioaerosols Emissions from Compost' Atmosphere 9, (10) 379-379 , DOI Open access
(2018) 'Sources of Airborne Endotoxins in Ambient Air and Exposure of Nearby Communities—A Review' Atmosphere 9, (10) 375-375 , DOI Open access
(2018) 'Spheroid Size Does not Impact Metabolism of the beta-blocker Propranolol in 3D Intestinal Fish Model' Frontiers in Pharmacology 9, , DOI Open access
(2018) 'Scoping studies to establish the capability and utility of a real-time bioaerosol sensor to characterise emissions from environmental sources' Science of the Total Environment 648, 25-32 , DOI Open access
(2018) 'TOWARDS IMPROVED BIOAEROSOL MODEL VALIDATION AND VERIFICATION' Air Pollution XXVI 230, (10) 41-50 , DOI Open access
(2018) 'Isolation of Oropouche Virus from Febrile Patient, Ecuador' Emerging Infectious Diseases 24, (5) 935-937 , DOI Open access
(2017) 'Correction to “Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via <i>in Situ</i> Grafting of Aryl Diazonium”' Langmuir: the ACS journal of surfaces and colloids 33, (50) , DOI Open access
(2017) 'Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper' Ecotoxicology 26, (8) 1117-1133 , DOI Open access
(2017) 'Evaluation of recombinant factor C assay for the detection of divergent lipopolysaccharide structural species and comparison with Limulus amebocyte lysate-based assays and a human monocyte activity assay' Journal of Medical Microbiology 66, (7) 888-897 , DOI
(2017) 'Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via <i>in Situ</i> Grafting of Aryl Diazonium' Langmuir 33, (20) 4924-4933 , DOI
(2017) 'THE CHALLENGES, UNCERTAINTIES AND OPPORTUNITIES OF BIOAEROSOL DISPERSION MODELLING FROM OPEN COMPOSTING FACILITIES' WIT Transactions on Ecology and the Environment , DOI
(2017) 'Exposure to Porphyromonas gingivalis LPS during macrophage polarisation leads to diminished inflammatory cytokine production' Archives of Oral Biology 81, 41-47 , DOI Open access
(2017) 'Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance' PLOS ONE 12, (1) e0168837-e0168837 , DOI Open access
(2016) 'Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes' Scientific Reports 6, 37672-37672 , DOI Open access
(2016) 'Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry' PLOS ONE 11, (8) e0160795-e0160795 , DOI Open access
(2016) 'Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry' PLOS ONE 11, (2) e0149492-e0149492 , DOI Open access
(2015) 'Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor' ACS Applied Materials & Interfaces 7, (42) 23527-23537 , DOI Open access
(2015) 'The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons' Neuroscience 310, 686-698 , DOI Open access
(2015) 'Amperometric Screen-Printed Galactose Biosensor for Cell Toxicity Applications' Analytical Letters 49, (2) 236-244 , DOI
(2015) 'Lysophosphatidylcholine Acyltransferase (LPCAT)‐ 2 Co‐localises with TLR4 and Regulates Macrophage Inflammatory Gene expression in Response to LPS' The FASEB Journal 29, , DOI
(2014) 'Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers' Sensors (Basel) 14, (11) 20519-20532 , DOI Open access
(2014) 'The potential of lipopolysaccharide as a real-time biomarker of bacterial contamination in marine bathing water' J Water Health 12, (1) 105-112 , DOI
(2014) 'Overexpression of lysophosphatidylcholine acyltransferase 2 (LPCAT2) up-regulated LPS-induced responses in a murine macrophage' IMMUNOLOGY 143, 104-105
(2014) 'Fish cell lines in 3 dimensional (3D) cultures in ecotoxicological studies: is there oxygen in the middle?' MUTAGENESIS 29, (6) 539-540
(2013) 'Development of an amperometric screen-printed galactose biosensor for serum analysis' Anal Biochem 435, (2) 114-119 , DOI
(2013) 'Microfabricated glucose biosensor for culture well operation' Biosens Bioelectron 42, 668-677 , DOI
(2013) 'Tailoring 3D Single-Walled Carbon Nanotubes Anchored to Indium Tin Oxide for Natural Cellular Uptake and Intracellular Sensing' NANO LETTERS 13, (1) 1-8 , DOI Open access
(2013) 'In-vitro maintenance and functionality of primary renal tubules and their application in the study of relative renal toxicity of nephrotoxic drugs' J Pharmacol Toxicol Methods 68, (2) 269-274 , DOI
(2013) 'Intracellular ‘wiring’ for real-time cell communication' Nano Reviews 4, (1) 22429-22429 , DOI
(2012) 'Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes' Ecotoxicology 21, (8) 2419-2429 , DOI
(2012) 'Development of a sandwich format, amperometric screen-printed uric acid biosensor for urine analysis' Anal Biochem 428, (1) 39-43 , DOI
(2012) '3D spheroidal fish hepatocytes as an alternative <i>in vitro</i> model for environmental toxicology' MUTAGENESIS 27, (6) 800-800
(2011) 'Neisseria lactamica attenuates TLR-1/2-induced cytokine responses in nasopharyngeal epithelial cells using PPAR-γ' Cell Microbiol 13, (4) 554-568 , DOI
(2011) 'Evaluation of inflammatory effects of airborne endotoxin emitted from composting sources' Environ Toxicol Chem 30, (3) 602-606 , DOI
(2011) 'Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures' Innate Immun 17, (3) 245-255 , DOI
(2011) 'A screen-printed microband glucose biosensor system for real-time monitoring of toxicity in cell culture' Biosens Bioelectron 26, (5) 2448-2453 , DOI
(2011) 'Spatial variations in airborne microorganism and endotoxin concentrations at green waste composting facilities' INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 214, (5) 376-383 , DOI
(2010) 'Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains' J Lipid Res 51, (2) 334-344 , DOI
(2010) 'Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins' MICROCHIMICA ACTA 170, (3-4) 321-330 , DOI
(2010) 'VOLTAMMETRIC BEHAVIOR OF DNA AND ITS DERIVATIVES USING SCREEN PRINTED CARBON ELECTRODES AND ITS POSSIBLE APPLICATION IN GENOTOXICITY SCREENING' ANALYTICAL LETTERS 43, (10-11) 1790-1800 , DOI
(2009) 'Current considerations for the effective safety evaluation of drugs in vitro' Mini Rev Med Chem 9, (7) 861-868 , DOI
(2009) 'Application of screen-printed microband biosensors to end-point measurements of glucose and cell numbers in HepG2 cell culture' Anal Biochem 385, (2) 334-341 , DOI
(2009) 'Particle size distribution of airborne <i>Aspergillus fumigatus</i> spores emitted from compost using membrane filtration' ATMOSPHERIC ENVIRONMENT 43, (35) 5698-5701 , DOI
(2008) 'Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap' Toxicol In Vitro 22, (5) 1321-1331 , DOI
(2008) 'Lysophospholipid acyltransferases: novel potential regulators of the inflammatory response and target for new drug discovery' Pharmacol Ther 119, (1) 104-114 , DOI
(2008) 'Lysophospholipid metabolism facilitates Toll-like receptor 4 membrane translocation to regulate the inflammatory response' J Leukoc Biol 84, (1) 86-92 , DOI
(2008) 'DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB' Biochem Biophys Res Commun 370, (1) 174-178 , DOI
(2008) 'Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus--an effect probably mediated by direct platelet PPARgamma activation' Atherosclerosis 197, (2) 718-724 , DOI
(2008) 'Molecular detection of exercise-induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial' DIABETOLOGIA 51, (11) 2049-2059 , DOI
(2007) 'Functional three-dimensional HepG2 aggregate cultures generated from an ultrasound trap: comparison with HepG2 spheroids' J Cell Biochem 102, (5) 1180-1189 , DOI
(2007) 'Highly purified lipopolysaccharides from Burkholderia cepacia complex clinical isolates induce inflammatory cytokine responses via TLR4-mediated MAPK signalling pathways and activation of NFkappaB' Cell Microbiol 9, (2) 532-543 , DOI
(2007) 'Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle' FREE RADICAL RESEARCH 41, (2) 182-190 , DOI
(2006) 'Free radical production and quenching in honeys with wound healing potential' J Antimicrob Chemother 58, (4) 773-777 , DOI
(2006) 'Prolonged deterioration of endothelial dysfunction in response to postprandial lipaemia is attenuated by vitamin C in Type 2 diabetes' DIABETIC MEDICINE 23, (3) 258-264 , DOI
(2006) 'The use of <i>lux</i> genes for monitoring the uptake of <i>Pseudomonas</i> <i>aeruginosa</i> by respiratory epithelial cells' LUMINESCENCE 21, (5) 289-289
(2005) 'Surfactant phospholipid DPPC downregulates monocyte respiratory burst via modulation of PKC' Am J Physiol Lung Cell Mol Physiol 288, (6) L1070-L1080 , DOI
(2005) 'Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes' Diab Vasc Dis Res 2, (2) 88-93 , DOI
(2005) 'The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma' Biochim Biophys Acta 1733, (2-3) 232-238 , DOI
(2004) 'Tissue oxygenation in sepsis; new insights from in vivo EPR' NMR Biomed 17, (5) 319-326 , DOI
(2004) 'Evidence against redox regulation of energy homoeostasis in humans at high altitude' CLINICAL SCIENCE 107, (6) 589-600 , DOI
(2004) 'G-irradiation of ultrahigh-molecular-weight polyethylene: Electron paramagnetic resonance and nuclear magnetic resonance spectroscopy and imaging studies of the mechanism of subsurface oxidation' JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 42, (23) 5929-5941 , DOI
(2004) 'Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure' Eur J Heart Fail 6, (1) 47-54 , DOI
(2004) 'In vivo EPR spectroscopy: biomedical and potential diagnostic applications' Faraday Discuss 126, 103-117 , DOI
(2004) 'Lysophospholipid acyltransferases in monocyte inflammatory responses and sepsis' Immunobiology 209, (1-2) 31-38 , DOI
(2003) 'Exercise-induced endotoxemia: the effect of ascorbic acid supplementation' Free Radic Biol Med 35, (3) 284-291 , DOI
(2003) 'Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide' Eur J Biochem 270, (13) 2782-2788 , DOI
(2003) 'Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine' J Leukoc Biol 74, (1) 95-101 , DOI
(2003) 'Comparison of cross-linked polyethylene materials for orthopaedic applications' CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (414) 289-304 , DOI
(2003) 'Variation in blood oxygenation and cerebral pO2 in a mouse model measured by EPR spectrometry' Adv Exp Med Biol 510, 205-211 , DOI
(2002) 'Antibacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock' Biochim Biophys Acta 1588, (3) 232-240 , DOI
(2002) 'Detection and removal of contaminating hydroxylamines from the spin trap DEPMPO, and re-evaluation of its use to indicate nitrone radical cation formation and S(N)1 reactions' Free Radic Biol Med 32, (3) 228-232 , DOI
(2002) 'Exercise, free radicals, and lipid peroxidation in type 1 diabetes mellitus' FREE RADICAL BIOLOGY AND MEDICINE 33, (11) 1543-1551 , DOI
(2002) 'Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress' EUROPEAN JOURNAL OF HEART FAILURE 4, (2) 193-199 , DOI
(2002) 'Endotoxin-induced liver hypoxia: Defective oxygen delivery versus oxygen consumption' NITRIC OXIDE-BIOLOGY AND CHEMISTRY 6, (1) 18-28 , DOI
(2001) 'Acylation of Lysophosphatidylcholine is Crucial to the Monocyte Response to LPS' Biochemical Society Transactions 29, (5) A129-A129 , DOI
(2001) 'Firefly flashing is controlled by gating oxygen to light-emitting cells' J Exp Biol 204, (Pt 16) 2795-2801 , DOI
(2001) 'Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure' J Cardiovasc Pharmacol 37, (5) 564-570 , DOI
(2001) 'Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases' Clin Exp Immunol 124, (1) 86-94 , DOI
(2001) 'The evolution of bioluminescent oxygen consumption as an ancient oxygen detoxification mechanism' J Mol Evol 52, (4) 321-332 , DOI
(2001) 'Applications of in vivo electron paramagnetic resonance (EPR) spectroscopy: measurements of pO2 and NO in endotoxin shock' Toxicol Lett 120, (1-3) 253-257 , DOI
(2001) 'Evidence against oxidative stress as mechanism of endothelial dysfunction in methionine loading model' Am J Physiol Heart Circ Physiol 280, (3) H1334-H1339 , DOI
(2001) 'The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes' Atherosclerosis 154, (2) 475-483 , DOI
(2001) 'Vitamin C Therapy Attenuates Oxitative Stress and Restores Endothelial Function in Young Patients with Familial Hypercholesterolaemia' Clinical Science 100, (s44) 7P-7P , DOI
(2001) 'Pulmonary surfactant and DPPC inhibit superoxide production in monocytes' BLOOD 98, (11) 227A-227A
(2001) 'Synthesis of platelet-activating factor (PAF) in monocytic cells is inhibited by dipalmitoyl phosphatidylcholine via inhibition of enzymes of the remodelling pathway' BLOOD 98, (11) 226A-226A
(2001) 'There is prolonged post-prandial lipaemia-induced endothelial dysfunction in type 2 diabetes and is reversible with vitamin C therapy' EUROPEAN HEART JOURNAL 22, 157-157
(2001) 'Diagnosis of Gram negative, ventilator associated pneumonia by assaying endotoxin in bronchial lavage fluid' JOURNAL OF CLINICAL PATHOLOGY 54, (2) 107-110 , DOI
(2000) 'Neutrophil superoxide anion–generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy' Journal of the American College of Cardiology 36, (5) 1474-1482 , DOI
(2000) 'PROSTAGLANDIN E2AND TUMOUR NECROSIS FACTOR-α RELEASE BY MONOCYTES ARE MODULATED BY PHOSPHOLIPIDS' Cytokine 12, (11) 1717-1719 , DOI
(2000) 'Primary nitric oxide resistance and oxidative stress in patients with chronic heart failure' Heart 83, (SUPPL. 1)
(2000) 'Ciprofibrate Therapy Improves Endothelial Function and Reduces Postprandial Lipemia and Oxidative Stress in Type 2 Diabetes Mellitus' Circulation 101, (15) 1773-1779 , DOI
(2000) 'The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency' European Journal of Endocrinology 254-262 , DOI
(2000) 'Combination therapy with an angiotensin II antagonist and angiotensin converting enzyme inhibitors have no effect on endothelial function and oxidative stress in chronic heart failure' CIRCULATION 102, (18) 535-535
(2000) 'Fasting and postprandial platelet nitrate responsiveness in type 2 diabetes' CIRCULATION 102, (18) 334-334
(1999) 'Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study' Journal of Applied Physiology 87, (6) 2032-2036 , DOI
(1999) 'An EPR investigation of surfactant action on bacterial membranes' FEMS Microbiology Letters 177, (1) 57-62 , DOI
(1999) 'NIDDM subjects exhibit an increase in lipid peroxidation and augmented endothelial dysfunction in response to post-prandial lipaemia' Heart 81, (SUPPL. 1)
(1999) 'Oxidative stress is greater in patients with chronic heart failure due to coronary artery disease' Heart 81, (SUPPL. 1)
(1999) 'Vitamin C improves arterial distensibility following maximal exercise in healthy subjects' Heart 81, (SUPPL. 1)
(1999) 'Lipopolysaccharide (LPS) from
<i>Burkholderia cepacia</i>
Is More Active than LPS from
<i>Pseudomonas aeruginosa</i>
and
<i>Stenotrophomonas maltophilia</i>
in Stimulating Tumor Necrosis Factor Alpha from Human Monocytes' Infection and Immunity 67, (3) 1505-1507 , DOI
(1999) 'Post-Prandial Lipaemia is Associated with Augmented Free Radical Release and Endothelial Dysfunction in Diabetics Compared with Healthy Controls' Clinical Science 96, (s40) 2P-2P , DOI
(1999) 'A Melanin Pigment Purified from an Epidemic Strain of
<i>Burkholderia cepacia</i>
Attenuates Monocyte Respiratory Burst Activity by Scavenging Superoxide Anion' Infection and Immunity 67, (2) 908-913 , DOI
(1998) 'Electron spin resonance spectroscopic detection of oxygen-centred radicals in human serum following exhaustive exercise' European Journal of Applied Physiology 77, (6) 498-502 , DOI
(1998) 'Free radical levels are increased in venous blood in dilated cardiomyopathy' Heart 79, (SUPPL. 1)
(1998) 'The ability of neutrophils to generate superoxide anions is increased in chronic heart failure and correlates with NYHA status' Heart 79, (SUPPL. 1)
(1998) 'Generation of Superoxide Anion by Neutrophils and Venous Free Radical Levels Are Increased in Patients with Chronic Heart Failure' Clinical Science 94, (s38) 20P-20P , DOI
(1998) 'Detection of human TNF-α mRNA by NASBA™' Journal of Immunological Methods 212, (1) 19-28 , DOI
(1997) 'Role of lipid metabolites in the signalling and activation of macrophage cells by lipopolysaccharide' Progress in Lipid Research 36, (4) 227-244 , DOI
(1997) 'The addition of nitric oxide to 1,5-dimethylhexa-2,4-diene; X-ray crystal structure determination of the major product, (E)-2,5-dimethyl-2,5-dinitrohex-3-ene' Tetrahedron 53, (50) 17221-17234 , DOI
(1997) 'ChemInform Abstract: The Addition of Nitric Oxide to 2,5‐Dimethyl‐hexa‐2,4‐diene Gives Nitrogen Dioxide Adducts' ChemInform 28, (23) , DOI
(1997) 'ROLE OF ACYLTRANSFERASES IN SENSITIZING HUMAN MONOCYTES TO LIPOPOLYSACCHARIDE' Shock 7, (Supplement) 36-36 , DOI
(1997) 'The addition of nitric oxide to 2,5-dimethyl-hexa-2,4-diene gives nitrogen dioxide adducts' Tetrahedron Letters 38, (7) 1245-1248 , DOI
(1997) 'Effect of temperature on aminoglycoside binding sites in Stenotrophomonas maltophilia' Journal of Antimicrobial Chemotherapy 39, (1) 19-24 , DOI
(1996) 'Endotoxin-induced changes in intrarenal pO2, measured by in vivo electron paramagnetic resonance oximetry and magnetic resonance imaging' Free Radical Biology and Medicine 21, (1) 25-34 , DOI
(1996) 'Lipopolysaccharide decreases oxygen consumption by Mono Mac 6 cells; an electron paramagnetic resonance oximetry study' Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1310, (1) 5-9 , DOI
(1996) 'Opposite effects of interleukin-4 and interleukin-10 on nitric oxide production in murine macrophages' Mediators of Inflammation 5, (2) 110-112 , DOI
(1996) 'Temperature-dependent aminoglycoside resistance in <i>Stenotrophomonas (Xanthomonas) maltophilia;</i> alterations in protein and lipopolysaccharide with growth temperature' Journal of Antimicrobial Chemotherapy 37, (4) 665-676 , DOI
(1995) 'Differential effects of interferon-gamma and -beta on fatty acid turnover, lipid bilayer fluidity and TNF-alpha release in murine macrophage J774.2 cells' Int J Exp Pathol 76, (5) 331-337
(1995) 'The effects of endotoxin on oxygen consumption of various cell types in vitro: An EPR oximetry study' Free Radical Biology and Medicine 18, (4) 641-647 , DOI
(1995) 'Antigenaemia during acute graft versus host disease' Journal of Clinical Pathology 48, (2) 105-109 , DOI
(1995) 'Growth temperature-dependent variation of cell envelope lipids and antibiotic susceptibility in <i>Stenotrophomonas (Xanthomonas) maltophilia</i>' Journal of Antimicrobial Chemotherapy 36, (2) 317-326 , DOI
(1995) 'Macrophage activation by lipopolysaccharide, interferon-γ and interleukin-4: effect of fatty acid metabolism' Mediators of Inflammation 4, (1) 25-30 , DOI
(1994) 'Interferon-gamma and polyunsaturated fatty acids increase the binding of lipopolysaccharide to macrophages' Int J Exp Pathol 75, (5) 363-368
(1994) 'Pyrolysis mass spectrometry characterisation and numerical taxonomy ofAeromonas spp' Antonie van Leeuwenhoek 64, (3-4) 315-323 , DOI
(1993) 'Effect of Interferon-γ on Membrane Conformation in the Macrophage-Like Cell Line P388D' Journal of Interferon Research 13, (6) 427-431 , DOI
(1993) 'Interferon-γ-Stimulated Uptake and Turnover of Linoleate and Arachidonate in Macrophages: A Possible Pathway for Hypersensitivity to Endotoxin' Cellular Immunology 152, (1) 59-71 , DOI
(1993) 'Effect of IgM‐enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti‐endotoxin antibodies in bone marrow transplantation' European Journal of Clinical Investigation 23, (9) 540-545 , DOI
(1993) 'Unusual infections and novel therapeutic strategies' Current Opinion in Infectious Diseases 6, (3) 427-431
(1992) 'Interferon-gamma increases macrophage phospholipid polyunsaturation: a possible mechanism of endotoxin sensitivity' Int J Exp Pathol 73, (6) 783-791
(1992) 'Binding of spin-labelled analogues of endotoxin to serum proteins' Applied Magnetic Resonance 3, (5) 815-825 , DOI
(1992) 'Binding of endotoxin to macrophages; interactions of spin-labelled saccharide residues' Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1135, (2) 165-170 , DOI
(1992) 'Use of IgM enriched intravenous immunoglobulin (Pentaglobin) in bone marrow transplantation' Bone Marrow Transplant 9, (6) 451-457
(1992) 'Molecular interactions between bacterial endotoxins and mammalian cells. A spin-label study' Journal of the Chemical Society, Perkin Transactions 2 (9) 1503-1503 , DOI
(1990) 'Sensitivity to endotoxin is induced by increased membrane fatty-acid unsaturation and oxidant stress' Journal of Medical Microbiology 32, (4) 217-221 , DOI
(1990) 'Serum immunoglobulins to endotoxin core glycolipid: acute leukaemia and other cancers' Archives of Disease in Childhood 65, (7) 771-773 , DOI
(1990) 'Serum immunoglobulins to endotoxin core glycolipid: establishment of normal concentrations' Archives of Disease in Childhood 65, (7) 768-770 , DOI
(1990) 'The effect of endotoxin on membrane fatty acid composition in BCG-sensitized mice' Experientia 46, (5) 472-474 , DOI
(1989) 'Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin' Br J Exp Pathol 70, (4) 435-441
(1989) 'Effects of<i>E. Coli</i>0111.B4 Lipopolysaccharide on Spin-Labelled Murine Macrophage and Hepatocyte Membranes' Free Radical Research Communications 8, (1) 47-53 , DOI
(1989) 'Electron spin resonance detection of oxygen-centred radicals in murine macrophages stimulated with bacterial endotoxin' Free Radical Biology and Medicine 7, (2) 165-170 , DOI
(1988) 'Is gram-negative shock a free-radical-mediated condition?' Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases 84, (10) 3243-3243 , DOI
(1987) 'Tissue oxidation after endotoxin' Bioelectrochemistry and Bioenergetics 18, (1-3) 301-306 , DOI
(1987) 'Tumour cell killing by tumour necrosis factor: inhibition by anaerobic conditions, free-radical scavengers and inhibitors of arachidonate metabolism' Immunology 62, (1) 153-155
(1986) 'Covalent binding of human serum albumin and ovalbumin by chloramine-T and chemical modification of the proteins' Analytica Chimica Acta 186, 319-323 , DOI
(1985) 'Identification of radicals spin‐trapped in autoxidized linoleic acids: A high performance liquid chromatography and electron spin resonance study' Journal of High Resolution Chromatography 8, (12) 829-830 , DOI
(1985) 'ENDOR, triple resonance and ESR studies of spin-trapped radicals in autoxidized linoleic acid and its deuterated derivatives' Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 835, (3) 421-425 , DOI
(1985) 'An electron spin resonance study of radicals from chloramine-t-1' Tetrahedron 41, (22) 5191-5194 , DOI
(1985) 'An electron spin resonance study of radicals from chloramine-T—2' Tetrahedron 41, (22) 5195-5200 , DOI
(1984) 'Endor and ESR studies of spin-trapped radicals in autoxidized unsaturated fatty acid methyl esters' Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 792, (2) 239-242 , DOI
Chapters
(2022) 'Compendium of analytical methods for sampling, characterization and quantification of bioaerosols' Advances in Ecological Research Elsevier 101-229 , DOI
(2019) 'Applications of Electron Paramagnetic Resonance (EPR) Spectroscopy in the Study of Oxidative Stress in Biological Systems' Redox-Mediated Signal Transduction Springer US 93-102 , DOI
(2006) 'Biological Free Radicals and Biomedical Applications of EPR Spectroscopy' Electron Paramagnetic Resonance The Royal Society of Chemistry 192-244 , DOI
Conference Papers
(2020) 'Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS' Springer Science and Business Media LLC , DOI Open access
(2016) 'A novel alveolar-like macrophage to study influenza A infection <i>in vitro</i>' 438-438
(2016) 'Development and characterization of a novel cell-based biosensor for screening of inflammatory agents in bioaerosols' 1176-1176
(2016) 'Lysophosphatidylcholine acyltransferase (LPCAT) 2 regulates macrophage inflammatory responses through acylation of key metabolic proteins' 837-837
(2010) '<i>Neisseria lactamica</i> attenuates TLR 1/2 - induced cytokine responses in nasopharyngeal epithelial cells using PPAR-gamma' 54-54
(2009) 'Microbial and endotoxin emission from composting facilities: characterisation of release and dispersal patterns' AIR POLLUTION 2009 7-/-0/20097-/-0/2009WIT Press , DOI
(2007) 'THE USE OF LUXGENES FOR MONITORING UPTAKE OF <i>PSEUDOMONAS AERUGINOSA</i> BY RESPIRATORY EPITHELIAL CELLS' 127-130 , DOI
(2005) 'Vascular benefits of rosigltazone and metformin compared with sulphonylurea and metformin combination therapy' S4-S4
(2004) 'Oxidative stress, the matrix and the pathogenesis of abdominal aortic aneurysms (AAAs)' 1233-1233
(2003) 'Influence of neuronally derived nitric oxide on blood oxygenation and cerebral pO<sub>2</sub> in a mouse model measured by EPR spectrometry' 257-263
(2002) 'Endothelial cell adhesion molecules and their influence on monocyte tissue factor expression' 266A-266A
(2002) 'Phospholipids modulate arachidonic acid metabolism in monocytic cells' 44B-45B
(2002) 'Pulmonary surfactant phospholipids selectively modulate inflammatory mediator production in monocytes and macrophages' 457A-457A
(1999) 'Phospholipid modulation of monocyte oxidative activity measured by luminol‐enhanced chemiluminescence' Wiley , DOI
(1997) 'The effects of inflammatory cytokines on acyl coenzymeA-dependent acyltransferase' Portland Press Ltd. 496S-496S , DOI
(1997) 'Effect of Lipopolysaccharide on Intra-Phagosomal Oxygen Concentration as Measured by EPR Oximetry' Springer US 613-620 , DOI
Presentations and posters
'EPR spectroscopic detection of semiquinone radicals in human skeletal muscle; - Focus on exercise and age'
'Upregulated innate immune responses in a hepatitis C virus exposed uninfected cohort' , DOI
'EPR Spectroscopic Detection of Semiquinone Radicals in Human Skeletal Muscle; Focus on Exercise and Age' , DOI
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Other academic activities
Editorial Board, Innate Immunity
Expert panel member, models of sepsis research, RSPCA