Dr Svetislav Zaric
Profiles

Dr Svetislav Zaric

Clinical Associate Professor in Biomedical Science

Peninsula Dental School (Faculty of Medicine and Dentistry)

Role


Clinical Senior Lecturer in Biomedical Science
Year 1 Lead for BDS and BSc DTH Programmes, Peninsula Dental School

Qualifications


2003. Bachelor of Dental Surgery, University of Belgrade, Serbia

2007. MClinDent in Periodontology and Oral Medicine, University of Belgrade, Serbia

2010. PhD in Microbiology/Immunology, Queen's University, Belfast

2014. Fellow of the Higher Education Academy



Previous positions:


2011-2013. Lecturer in Oral Biology, School of Dentistry, University of Aberdeen
2010-2011. Research Fellow, Centre for Infection and Immunity, Queen's University Belfast

Professional membership


- General Dental Council - 253538
- International Association for Dental Research
- British Society for Oral and Dental Research
- Association of Basic Science Teachers in Dentistry

Roles on external bodies

Editorial Board Member:


- Journal of Clinical Periodontology
- Plos One
- International Journal of Molecular Sciences
- Journal of Oral Health and Dental Management
- Cochrane Upper Gastrointestinal and Pancreatic Diseases Group

Teaching interests


Oral Microbiology and Immunology, Histology,  Periodontology, Enquiry-Based Learning.

Research interests

My research interests include microbiology of periodontal diseases, host-pathogen interactions, Toll-Like Receptors signalling, immunopathogenesis of chronic inflammation and mechanisms involved in the resolution of inflammatory response (endotoxin tolerance). I am particularly interested in the chemical composition of Porphyromonas gingivalis LPS, with regards to its lipid-A structure and sialylation, and in consequences these changes have on the host’s immune response.  Other areas of my research interest are molecular and cellular mechanisms responsible for tissue injury during inflammation, biomarkers of periodontal disease progression, personalised, point-of-care periodontal therapy and identification of therapeutic targets for resolution of inflammation.

https://www.plymouth.ac.uk/research/biomedical-research-group/periodontal-research

https://worldwide.espacenet.com/publicationDetails/biblio?DB=EPODOC&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20171101&CC=GB&NR=2549712A&KC=A

Figure 1: Mitochondrial transmembrane potential in neutrophils incubated with naive and P.gingivalis LPS tolerized monocytes.

Research degrees awarded to supervised students


MSc project:  "Immunomodulatory effects of viral TLR ligands on subsequent bacterial infection", student: Ye Zhang.
PhD project: " Tolerogenic mechanisms and macrophage polarisation associated with periodontal pathogen Porphyromonas gingivalis", Alex Strachan.

Key publications are highlighted

Journals
Articles
Zaric SS, Lappin MJ, Fulton CR, Lundy FT, Coulter WA & Irwin CR 2017 'Sialylation of Porphyromonas gingivalis LPS and its effect on bacterial-host interactions' Innate Immun 1753425917694245-1753425917694245 Author Site , DOI PEARL
Lappin MJ, Brown V, Zaric SS, Lundy FT, Coulter WA & Irwin CR 2015 'Interferon-γ stimulates CD14, TLR2 and TLR4 mRNA expression in gingival fibroblasts increasing responsiveness to bacterial challenge' Arch Oral Biol 61, 36-43 Author Site , DOI
Zaric S & Belfield LA 2015 'Objective Structured Clinical Examination (OSCE) with Immediate Feedback in Early (Preclinical) Stages of the Dental Curriculum' Creative Education 585-593 , DOI PEARL
Zaric S, Bojic B, Popovic B & Milasin J 2015 'Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating' Journal of Contemporary Dental Practice 16, (3) 205-209 , DOI PEARL
Yuen WY, Pasmooij AM, Stellingsma C & Jonkman MF 2012 'Enamel Defects in Carriers of a Novel LAMA3 Mutation Underlying Epidermolysis Bullosa' Acta Derm Venereol , DOI PEARL
Zaric SS, Coulter WA, Shelburne CE, Fulton CR, Zaric MS, Scott A, Lappin MJ, Fitzgerald DC, Irwin CR & Taggart CC 2011 'Altered Toll-like Receptor 2-mediated Endotoxin Tolerance Is Related to Diminished Interferon β Production' Journal of Biological Chemistry 286, (34) 29492-29500 , DOI PEARL
Zaric S, Shelburne C, Darveau R, Quinn DJ, Weldon S, Taggart CC & Coulter WA 2010 'Impaired immune tolerance to Porphyromonas gingivalis lipopolysaccharide promotes neutrophil migration and decreased apoptosis' Infect Immun 78, (10) 4151-4156 Author Site , DOI PEARL
Zaric S, Bojic B, Jankovic L, Dapcevic B, Popovic B, Cakic S & Milasin J 2009 'Periodontal therapy improves gastric Helicobacter pylori eradication' J Dent Res 88, (10) 946-950 Author Site , DOI
Books
Zaric S & Salih V 2016 Chapter 8. "The Periodontal Ligament" in Essential Clinical Oral Biology by Prof. S.Creanor. John Wiley & Sons
Patents
2017 LIPID-A BASED BIOSENSORS FOR PREVENTION OF PERIODONTAL DISEASES AND PERSONALISED, POINT-OF-CARE PERIODONTAL THERAPY. GB2549712 Publisher Site

Additional information


- 2011. IADR/Hatton Divisional Award
- 2013. IADR/Lion Microbiology/Immunology Award
- 2013. GlaxoSmithKline/BSODR research grant

Links

https://www.plymouth.ac.uk/research/biomedical-research-group/infection-immunity-inflammation