Dr Torsten Bossing
Senior Technical Specialist
Institute of Translational & Stratified Medicine
Senior Research Fellow, Head of Imaging Suite at John Bull
1991 Diploma, Johannes Gutenberg University Mainz, Germany
Since2013 Teaching and Lecturing at Plymouth University
Personal Research Project (3001-X),
Methods in Human Biosciences (BHCS2019)
Evidence-Based Practice in Biomedical Sciences(BHCS2002)
Current Issues in Neurobiology (BHCS3007)
Master Research Project (BIOM5006)
Teaching and Supervision of undergraduates, postgraduates and staff in advanced microscopy
2012- 2013 Lecturer and Convener of ‘Neurobiology of CNS Disorders’, Bangor University
2011-2013 Lecturer in ‘Biosciences,Enterprise and Employability’, Bangor University
2010- 2013 Convener of the modules ‘CurrentTopics in Life Sciences’; ‘Experimental Projects’ and ‘Literature Projects’;Lecturer in Human Physiology – Brain Physiology; Head of the Third Year students, Personal Tutor at the School of Biological Sciences at Bangor University
since 2007 Supervision of postgraduate and undergraduate students during their research projects
Understanding the workings of the human central nervous system (CNS) with its millions of neurons generating trillions of connections is a formidable challenge. Fortunately, to uncover the basic rules, we can turn to simpler organisms. I am making use of the simple fruit fly Drosophila to study evolutionary conserved mechanisms in CNS development and disease. Using classical genetics, molecular biology, transgenics and micromanipulation I study the embryonic development of the CNS to understand how damage in the CNS can be repaired. I also investigate the transcriptional program ensuring the correct formation of neural networks
Research degrees awarded to supervised students
Grants & contracts
2015 PhDstipend awarded by Medical Faculty, Plymouth University (GBP 52k/ 3 years
2014 collaborator in BBSRCGrant (Responsive Mode), Principal Investigator Dr. Claudia Barros (GBP 390k/ 3years)
2012 Royal Society Research Grant (GBP14,8k/ 1 year)
2010 Tenovus Cancer Charity UK(co-supervisor, GBP 115k/ 4 years)
2009 ResearchLectureship sponsored by Bioscience, Environment and Agriculture Alliance (GBP220k/ 4 years)
2008 GeraldKerkut PhD Studentship (GBP 57k/ 3 years)
1998- 2007 WellcomeResearch Associate
1996- 1998 European Fellowship (Human Capital and Mobility)
1996 Prize forthe best Ph.D. Thesis at the Johannes Gutenberg University, Faculty of Biology
Sealey, M.A., Vourkou, E., Cowan, C.M., Bossing,T., Quraishe S., Grammenoudi, S., Skoulakis, E.M.C and Mudher, A. (2017): Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy. Neurobiology of Disease, doi: 10.1016/j.nbd.2017.05.003
Liu, B and Bossing, T. (2016): Single neuron transcriptomics identify SRSF/ SRprotein B52 as a regulator of axon growth and Choline acetyltransferase synthesis. SciRep. 11;6:34952. doi: 10.1038/srep34952.
Ding, R., Weynans K., Bossing, T.,Barros, C. and Berger, C (2016): The Hippo signaling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun29;7: 10510. doi: 10.1038/ncomms10510
Liu, B., Campos, E. M. and Bossing, T.(2014): Drosophila Embryos as Model to AssessCellular and Developmental Toxicity of Multi-Walled Carbon Nanotubes (MWCNT) in Living Organisms. PLoS One18;9(2):e88681. doi:10.1371/journal.pone.0088681
Bossing, T (corresponding author).,Barros, C.S., Fischer B., Russell, S. and Shepherd, D. (2012): Disruption of microtubules integrity initiates mitosis during CNS repair. Dev Cell 23, 433-440
Cowan, C, Bossing, T., Page A.,Shepherd, D. and Mudher, A. (2010): Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta Neuropathologica 120, 593-604
Choksi, S.P., Southall, T., Bossing, T.,Edoff, K., de Wit, E., van Steensel, B., Micklem, G., Brand, A.H. (2006): Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev Cell 11, 775-789.
Bossing, T.and Brand, A. H. (2006): Determination of cell fate along the antero-posterior axis of the Drosophila ventral midline. Development 133, 1001-1012
Bossing, T.and Brand, A. H. (2002a): Dephrin, a transmembrane Ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS. Development 129, 4205-4218.
Bossing, T.,Barros, C. S. and Brand A.H. (2002b): Rapid tissue-specific expression assay in living embryos. Genesis 34(1-2),123-126.
Dittrich, R, Bossing, T., Gould, A.P.,Technau, G.M. and Urban, J. (1997): The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins eagle and huckebein. Development 124, 2515-2525.
Landgraf, M., Bate, C.M, Bossing, T. andTechnau, G.M. (1997): The origin, location and projection of the embryonic abdominal motoneurons of Drosophila., J. Neurosci. 17, 9642-9655.
Schmidt, H., Rickert, C., Bossing, T.,Vef, O., Urban, J. and Technau, G.M. (1997): The embryonic CNS lineages of Drosophila melanogaster: II. The lineages derived from the dorsal part of the neuroectoderm. Dev. Biol.189,186-204.
Bossing, T.,Udolph, G., Doe, C.Q. and Technau, G.M. (1996): The embryonic CNS lineages of Drosophila melanogaster: I. The lineages derived from the ventral half of the truncal neuroectoderm. Dev. Biol.179, 41-61.
Bossing, T.,Technau, G.M. and Doe, C.Q. (1996): huckebein is required for glial specification and axon pathfinding in the NB1-1 and NB2-2 lineages in the Drosophila CNS. Mech.Dev. 55, 53-64.
Broadus, J., Skeath, J.B., Spana, E., Bossing,T., Technau, G.M. and Doe, C.Q. (1995): New neuroblast markers and the origin of the aCC/ pCC neurons in the Drosophila CNS. Mech. Dev. 54, 1-10.
Udolph, G., Lüer, K., Bossing, T. andTechnau, G.M. (1995): Commitment of CNS progenitors along the dorsoventral axis of Drosophila neuroectoderm. Science 269, 1278-1281.
Bossing, T.and Technau, G.M. (1994): The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling. Development 120, 1895-1906.
Udolph, G., Prokop, A., Bossing, T. andTechnau, G.M. (1993): A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants. Development 118, 765-775.