Shutting down the power of brain tumour initiation cells

Project title: Shutting down the power of brain tumour initiation cells

Reference number: PUPSMD-17-18-014

Start date: 1 October 2018

Director of Studies: Dr Claudia Barros

2nd Supervisor: Dr Charles Affourtit

3rd Supervisor: Dr Jon Gil-Ranedo

The Faculty of Medicine and Dentistry is seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Faculty is committed to research excellence with a recent £25 million investment in staff and facilities. Medical research in the Faculty was ranked first for outputs in REF2014. 

A PhD studentship is available in Dr Claudia Barros’ group. The project is devoted to characterize the role of novel candidate genes in brain tumour initiation identified in the laboratory. It will focus on investigating pathways acting in mitochondria, the cells’ power plants, but it is not restricted to it. Drosophila will be used to examine candidate genes in the conversion of normal neural stem lineage cells into brain tumour initiation cells via gain and loss of function assays, providing a unique opportunity to unravel their role in live brains at single-cell resolution. Translation of findings will be performed using glioma tumour samples and patient-derived glioblastoma stem cell lines. 

Applications are invited from suitably qualified graduates (first class or 2:1, equivalent), and preferably a relevant masters or extended laboratory research experience. International students must have an IELTS score of 7.0 or above (with no less than 6.5 in any element). We are looking for a candidate with experience in genetics, molecular biology, immunohistochemistry, cell culture, biochemistry and/or confocal imaging. A high interest in neural stem cell and brain tumour biology is a must.

For further information regarding the project, please contact Dr Claudia Barros. However, applications must be made in accordance with the details shown below.

Funding notes:

The studentship is supported for three years and includes full home/EU tuition fees plus a stipend of £14,777 per annum. The studentship will only fully fund those applicants who are eligible for home/EU fees with relevant qualifications. Applicants normally required to cover overseas fees will have to cover the difference between the home/EU and the overseas tuition fee rates. For the 18/19 academic year the difference in fee is £10,610. If you are selected you will be required to provide financial assurances. 

To apply:

Follow the link and select 'Apply now' to access the application form. Please mark the application with REF: PUPSMD-17-18-014 for the attention of Francesca Niedzielski. A project proposal is not required. 

Further information on the application process. For questions on the admissions process contact  

Closing date for applications is 12 noon on Sunday 29 April 2018

Shortlisted candidates will be invited for interview. We regret that we may not be able to respond to all applications. Applicants who have not received an offer of a place by Thursday 31 May 2018 should consider their application has been unsuccessful on this occasion.