Project title: Shutting down the power of brain tumour
Reference number: PUPSMD-17-18-014
Start date: 1 October 2018
Director of Studies: Dr Claudia Barros
2nd Supervisor: Dr Charles Affourtit
3rd Supervisor: Dr Jon Gil-Ranedo
The Faculty of Medicine and Dentistry is seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Faculty is committed to research excellence with a recent £25 million investment in staff and facilities. Medical research in the Faculty was ranked first for outputs in REF2014.
A PhD studentship is available in Dr Claudia Barros’ group. The project is devoted to characterize the role of novel candidate genes in brain tumour initiation identified in the laboratory. It will focus on investigating pathways acting in mitochondria, the cells’ power plants, but it is not restricted to it. Drosophila will be used to examine candidate genes in the conversion of normal neural stem lineage cells into brain tumour initiation cells via gain and loss of function assays, providing a unique opportunity to unravel their role in live brains at single-cell resolution. Translation of findings will be performed using glioma tumour samples and patient-derived glioblastoma stem cell lines.
Applications are invited from suitably qualified graduates (first class or 2:1, equivalent), and preferably a relevant masters or extended laboratory research experience. International students must have an IELTS score of 7.0 or above (with no less than 6.5 in any element). We are looking for a candidate with experience in genetics, molecular biology, immunohistochemistry, cell culture, biochemistry and/or confocal imaging. A high interest in neural stem cell and brain tumour biology is a must.
For further information regarding the project, please contact Dr Claudia Barros. However, applications must be made in accordance with the details shown below.