Project title: Gene therapy using a modified Netrin-1 gene to enhance peripheral nerve repair
Reference number: PUPSMD-17-18-015
Start date: 1 October 2018
Director of Studies: Dr Xin-peng Dun
2nd Supervisor: Professor David Parkinson
3rd Supervisor: Dr Xinzhong Li
Schools of Medicine and Dentistry (PUPSMD) are seeking to attract PhD
candidates to join their exciting and rapidly expanding programme of internationally
rated research. PUPSMD
are committed to research excellence, with a recent £25 million investment in staff and facilities. Medical
research at PUPSMD was ranked first for outputs in REF2014. Since 2014, the
Community and Primary Care research group have been awarded over £6 million of NIHR
research funding for designing and evaluating complex health interventions.
The Plymouth University Peninsula Schools of Medicine and Dentistry are seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Plymouth University Peninsula Schools of Medicine and Dentistry are committed to research excellence with a recent £25 million investment in staff and facilities. Medical research at PUPSMD was ranked first for outputs in REF2014.
Applications are invited from suitably qualified graduates, 2:1 or above. International students must also have an IELTS score of 7.0 or above (with no less than 6.5 in any element).
Peripheral nerve injuries are still common in modern society but functional recovery is often very poor with current therapeutic strategies. Gene therapies are promising adjuvant therapeutic strategies to enhance functional recovery of peripheral nerve repair. Netrin-1 was the first discovered axon guidance molecule and it plays important repair roles in the adult nervous system following injury. It not only can promote rapid axon extension but also has the ability to direct regenerating axons to their original targets (Reference: Xin-Peng Dun and David Parkinson. Role of Netrin-1 signalling in nerve regeneration. International Journal of Molecular Sciences, 2017). Adeno-associated viruses are currently among the most frequently used viral vectors for gene therapy. This PhD project will use an adeno-associated virus vector carrying a modified Netrin-1 gene to promote more rapid functional recovery of damaged peripheral nerves.
For further information regarding the project, please contact Dr Xin-peng Dun. However, applications must be made in accordance with the details shown below.