3 May 2017: Redox-regulated metabolons in Alzheimer's disease
- Speaker: Professor Myra Conway, UWE Bristol.
Alzheimer’s disease (AD) is a progressive condition associated with the production and deposition of amyloid plaques and neurofibrillary tangles, which lead to synaptic and neuronal damage, resulting in memory loss. A significant body of work supports the hypothesis that clearance of amyloid from the brain will improve cognition and delay AD progression. However, recent drug trials, particular to amyloid load, have been disappointing and although amyloid load has been reduced, improved cognition was not observed. In this talk Myra will explore pathways upstream of aggregate accumulation and discuss how through an understanding of nutrient load and the redox regulation of key metabolic proteins we may identify new therapeutic targets to delay AD onset. Myra will also highlight the importance of developing new diagnostics in particular with respect to measuring drug efficacy.
This seminar is arranged by the Institute of Translational and Stratified Medicine, within the Plymouth University Peninsula Schools of Medicine and Dentistry.
The audience for the ITSMED seminar includes a mix of academic staff (clinical and scientific), post-doctoral fellows, postgraduate students and occasionally undergraduate students. Speakers are invited to talk for approximately 40 minutes followed by an opportunity for questions at the end.
Contact for further information