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Profiles
Dr Chris Rollinson
Quality Assurance Manager
Peninsula Medical School (Faculty of Health)
Biography
Biography
have worked for over 20 years in both commercial and non-commercial organizations delivering clinical trials research. During this time, I have gained experience in a number of Clinical Trial roles such as; Auditing & Monitoring, Project Management, Scientific Advisor and Training Facilitator.
Qualifications
1993 to 2001. PhD, Neuro-physiology (part-time study): Physiology Group, King's College London, Strand, London WC2R 2LS.
1991 to 1993. MSc, Neuro-anatomy (part-time study): Anatomy & Physiology groups, King's College London, Strand, London WC2R 2LS.
1987 to 1989 BSc. (Hons), Ecology & Entomology: University of East London, Stratford, London.
1991 to 1993. MSc, Neuro-anatomy (part-time study): Anatomy & Physiology groups, King's College London, Strand, London WC2R 2LS.
1987 to 1989 BSc. (Hons), Ecology & Entomology: University of East London, Stratford, London.
Professional membership
Member of RQA (Research Quality Association)
Member of the Society of Biology (SB).
Member of the Society of Biology (SB).
Teaching
Teaching
Teaching interests
Currently a NIHR GCP Training Facilitator.
Research
Research
Research interests
Clinical Trials. Past research interests have included CNS, Blood-brain barrier, heat shock proteins, endothelial cell function, lectins, electron microscopy, immunohistochemistry, immunology and early phase clinical trials.
Publications
Publications
Journals
1. Rollinson, C.(1986) Cardiac grafts in mice. Poster presented to the 1986 IAT Congress at
Southampton University.
2. Rollinson, C.(1987) The production of new congenic strains of mice. Animal Tech.38: (2) 156.
3. Berkovitz, B.K.B. and Rollinson, C.(1993) Ultrastructural quantification of collagen in human chordae tendineae. Br Heart J. 69: 246-249.
4. Begley, D.J., Chen. Z.-D., Rollinson, C.and Abbott, N.J. (1994) Activity of P-glycoprotein (Multidrug resistance protein) in cultured immortalised rat brain microvascular endothelial cells (RBE4). J.Physiol.(Lond). 480, 9P.
5. Rollinson, C.,Coward, L., Parry, D., Franey, S. and Egleton, R. (1995) Mast cells within the rat brain. Neuroimmunomodulation.2: (6). 365.
6. Rollinson, C.,Lane, N.J. and Abbott, N.J. (1995) Characterisation of an immortalized cell line of brain endothethelial cells RBE4. Poster presented to the 2nd International Symposium: Drug Transport to the Brain. Amsterdam.
7. Begley, D.J., Lechardeur, D., Chen, Z.-D., Rollinson, C.,Bardoul, M., Roux, F.,Sherman, D. and Abbott, N.J. (1996) Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4. J. Neurochem. 67: 988-995.
8. Rollinson, C,and Butler, J. (1997) The silver/gold intensification of DAB-chromogen in immunocytochemistry. Microscopy and Analysis. 58: 19-20.
9. Maden, M., Graham, A., Gale, E., Rollinson, C.,and Zile, M. (1997) Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids. Development.124: 2799-2805.
10. Rollinson, C.,Berkovitz, BKB., Harding, AMC and Franey, SW. (1997) Effect of hypertension on collagen fibrils diameters in chordae tendineae. The Congress of the Institute of Biomedical Science.Birmingham.
11. Rollinson, Cand Abbott, NJ. (1997) Comparison of the phenotype of immortalized brain endothelium cells with in situbrain endothelium: A lectin and antibody study. J.Physiol (Lond). 505.P
12. Dolman, DEM., Anderson, P., Rollinson, C.and Abbott, NJ. (1997) Characterisation of a new in vitromodel of the blood-brain barrier (BBB). J.Physiol(Lond).505.P
13. Abbott, NJ., Dolman, DEM., Rollinson C.,Anderson P., Chishty, M., Reichel, A., Fahey, A., Easton, AS and Begley, DJ. (1998) Functional Studies on a novel in vitroblood-brain barrier model: ECV304/C6. Cerebral Vascular Biology Conference ‘Advances in the biology of the cerebral vasculature and the blood-brain barrier’. Oregon USA
14. Rollinson, C.,Shackell, B. and Maynard, V. (1999) Good Clinical Practice for Clinical Research Nurses. RCN South West Research Society Conference
15. Begley, D., Regina, A., Roux, F., Khan, E., Rollinson, C.and Abbott, J. (2000) The role of brain extracellular fluid production and efflux mechanisms in drug transport to the brain. InThe Blood- brain barrier and drug delivery to the CNS. Eds Begley,D., Bradbury, M. and Kreuter, J. Published by Marcel Dekker, Inc.
16. Jazrawi, R and Rollinson, C.(2001) The use of endotoxin in proof of concept studies. EPC. Feb: 66-70.
17. Rollinson, C.(2001) Careful selection of physicians is required to allay public fears in clinical trials. Drug Discovery Today. 6: 879.
18. Sneyd, JR., Bryson, P. and Rollinson, C. (2001) Drug development in the 21st century. Current Anaesthesia in critical care. 12: (6): 329-334.
19. Abbott NJ, Khan EU, Rollinson CM, Reichel A, Janigro D, Dombrowski SM, Dobbie MS, Begley DJ. (2002) Drug resistance in epilepsy: role of the blood-brain barrier. Novartis Found Symp. 243:38-47; discussion 47-53, 180-5.
20. Rollinson, C.and Abbott, N.J. (2002) Sodium arsenite does not upregulate P-glycoprotein in RBE4 brain endothelial cells. J. Vasc. Res. 29: (6) 555
21. Jarvis MA, Hansen FA, Rosenke K, Haddock E, Rollinson C, Rule S, et al. (2020) Evaluation of drugs for potential repurposing against COVID-19 using a tier-based scoring system. Antivir Ther.https://christie.openrepository.com/handle/10541/623252
22. Ashwin D Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, E Siobhan Creanor. (2022). Mental Imagery to Reduce Alcohol-related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol. BMJ Open;12(5): e060498. doi: 10.1136/bmjopen-2021-060498.
2. Rollinson, C.(1987) The production of new congenic strains of mice. Animal Tech.38: (2) 156.
3. Berkovitz, B.K.B. and Rollinson, C.(1993) Ultrastructural quantification of collagen in human chordae tendineae. Br Heart J. 69: 246-249.
4. Begley, D.J., Chen. Z.-D., Rollinson, C.and Abbott, N.J. (1994) Activity of P-glycoprotein (Multidrug resistance protein) in cultured immortalised rat brain microvascular endothelial cells (RBE4). J.Physiol.(Lond). 480, 9P.
5. Rollinson, C.,Coward, L., Parry, D., Franey, S. and Egleton, R. (1995) Mast cells within the rat brain. Neuroimmunomodulation.2: (6). 365.
6. Rollinson, C.,Lane, N.J. and Abbott, N.J. (1995) Characterisation of an immortalized cell line of brain endothethelial cells RBE4. Poster presented to the 2nd International Symposium: Drug Transport to the Brain. Amsterdam.
7. Begley, D.J., Lechardeur, D., Chen, Z.-D., Rollinson, C.,Bardoul, M., Roux, F.,Sherman, D. and Abbott, N.J. (1996) Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4. J. Neurochem. 67: 988-995.
8. Rollinson, C,and Butler, J. (1997) The silver/gold intensification of DAB-chromogen in immunocytochemistry. Microscopy and Analysis. 58: 19-20.
9. Maden, M., Graham, A., Gale, E., Rollinson, C.,and Zile, M. (1997) Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids. Development.124: 2799-2805.
10. Rollinson, C.,Berkovitz, BKB., Harding, AMC and Franey, SW. (1997) Effect of hypertension on collagen fibrils diameters in chordae tendineae. The Congress of the Institute of Biomedical Science.Birmingham.
11. Rollinson, Cand Abbott, NJ. (1997) Comparison of the phenotype of immortalized brain endothelium cells with in situbrain endothelium: A lectin and antibody study. J.Physiol (Lond). 505.P
12. Dolman, DEM., Anderson, P., Rollinson, C.and Abbott, NJ. (1997) Characterisation of a new in vitromodel of the blood-brain barrier (BBB). J.Physiol(Lond).505.P
13. Abbott, NJ., Dolman, DEM., Rollinson C.,Anderson P., Chishty, M., Reichel, A., Fahey, A., Easton, AS and Begley, DJ. (1998) Functional Studies on a novel in vitroblood-brain barrier model: ECV304/C6. Cerebral Vascular Biology Conference ‘Advances in the biology of the cerebral vasculature and the blood-brain barrier’. Oregon USA
14. Rollinson, C.,Shackell, B. and Maynard, V. (1999) Good Clinical Practice for Clinical Research Nurses. RCN South West Research Society Conference
15. Begley, D., Regina, A., Roux, F., Khan, E., Rollinson, C.and Abbott, J. (2000) The role of brain extracellular fluid production and efflux mechanisms in drug transport to the brain. InThe Blood- brain barrier and drug delivery to the CNS. Eds Begley,D., Bradbury, M. and Kreuter, J. Published by Marcel Dekker, Inc.
16. Jazrawi, R and Rollinson, C.(2001) The use of endotoxin in proof of concept studies. EPC. Feb: 66-70.
17. Rollinson, C.(2001) Careful selection of physicians is required to allay public fears in clinical trials. Drug Discovery Today. 6: 879.
18. Sneyd, JR., Bryson, P. and Rollinson, C. (2001) Drug development in the 21st century. Current Anaesthesia in critical care. 12: (6): 329-334.
19. Abbott NJ, Khan EU, Rollinson CM, Reichel A, Janigro D, Dombrowski SM, Dobbie MS, Begley DJ. (2002) Drug resistance in epilepsy: role of the blood-brain barrier. Novartis Found Symp. 243:38-47; discussion 47-53, 180-5.
20. Rollinson, C.and Abbott, N.J. (2002) Sodium arsenite does not upregulate P-glycoprotein in RBE4 brain endothelial cells. J. Vasc. Res. 29: (6) 555
21. Jarvis MA, Hansen FA, Rosenke K, Haddock E, Rollinson C, Rule S, et al. (2020) Evaluation of drugs for potential repurposing against COVID-19 using a tier-based scoring system. Antivir Ther.https://christie.openrepository.com/handle/10541/623252
22. Ashwin D Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, E Siobhan Creanor. (2022). Mental Imagery to Reduce Alcohol-related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol. BMJ Open;12(5): e060498. doi: 10.1136/bmjopen-2021-060498.
Personal
Personal
Additional information
Sporting Interests: Sailing, Swimming, Running, Cycling, Aquathlon, Triathlon, Walking. Represented GB in Masters Aquathlon and Triathlon World and European Championship Events