Researchers have created a three-dimensional model of the oral mucosa that can be used in studies to test its response to a range of bacterial and other infections.
The model, created by experts in dentistry and immunology at the University of Plymouth, is formed from a collagen hydrogel containing cell types commonly found in the human body.
In a series of tests, the researchers analysed the model’s response to a range of pathogens including Candida albicans and Staphylococcus aureus.
They found it behaved similarly to responses observed in other studies involving real patients, indicating it could be implemented for the wider study of oral infection.
Specifically, they plan to use it to assess how the oral mucosa – the tissue similar to skin which lines the inside of the mouth, including the inside of cheeks and lips – might respond to long-term denture wear.
With epithelium not limited to the oral cavity, the researchers also believe such models may also have a potential research role for illnesses of the digestive system, such as Crohn’s disease.
The research was published in the Journal of Tissue Engineering, one of the world’s leading scientific publications covering research in the field of tissue engineering and its clinical application.
Vehid Salih
